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Tbio
ITIH3
Inter-alpha-trypsin inhibitor heavy chain H3

Protein Summary
Description
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449956
  • ENSP00000415769
  • ENSG00000162267

Symbol
  • H3P
  • SHAP
  • ITI-HC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
gene perturbation
0.87
phenotype
0.58
tissue sample
0.52
cell type or tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.3   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.3   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
CST7
Tbio
Novelty:  0.03651959
p_int:  0.995237679
p_ni:  0.004762315
p_wrong:  6e-9
Score:  0.274
Data Source:  BioPlex,STRINGDB
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.899015518
p_ni:  0.100982318
p_wrong:  0.000002165
Score:  0.555
Data Source:  BioPlex,STRINGDB
THTPA
Tbio
Family:  Enzyme
Novelty:  0.06922501
p_int:  0.832773928
p_ni:  0.167224723
p_wrong:  0.000001348
Score:  0.54
Data Source:  BioPlex,STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.956
Data Source:  STRINGDB
SPP2
Tbio
Novelty:  0.04515855
Score:  0.955
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.952
Data Source:  STRINGDB
ECM1
Tbio
Novelty:  0.00518679
Score:  0.927
Data Source:  STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.92
Data Source:  STRINGDB
SELENOP
Tbio
Novelty:  0.00194637
Score:  0.92
Data Source:  STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (62)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
10
22
97.2
body mass index
3
4
4
94.5
schizophrenia
9
6
2
1.1
93.3
5
3
1
1.1
92.3
BMI-adjusted waist circumference
5
12
14
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
22
97.2
body mass index
4
94.5
schizophrenia
2
1.1
93.3
1
1.1
92.3
BMI-adjusted waist circumference
14
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain 3
VGNC:7072
460436
Macaque
inter-alpha-trypsin inhibitor heavy chain 3
695200
Mouse
MGI:96620
16426
Rat
RGD:620633
50693
Dog
inter-alpha-trypsin inhibitor heavy chain H3
491368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain 3
Macaque
inter-alpha-trypsin inhibitor heavy chain 3
Mouse
Rat
Dog
inter-alpha-trypsin inhibitor heavy chain H3
Publication Statistics
PubMed Score 32.30
PubMed score by year
PubTator Score 16.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title