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Tbio
ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

Protein Summary
Description
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358415
  • ENSP00000351190
  • ENSG00000151655

Symbol
  • IGHEP2
  • H2P
  • SHAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.63
gene perturbation
0.6
kinase perturbation
0.6
cell type or tissue
0.57
small molecule perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.95   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.95   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
TNFAIP6
Tbio
Novelty:  0.0046811
p_int:  0.99995533
p_ni:  0.000044669
Score:  0.616
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.999843214
p_ni:  0.000156786
Score:  0.162
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.999707583
p_ni:  0.000292356
p_wrong:  6.1e-8
Data Source:  BioPlex
FCGR1A
Tclin
Novelty:  0.00073204
p_int:  0.99916906
p_ni:  0.000810464
p_wrong:  0.000020476
Score:  0.162
Data Source:  BioPlex,STRINGDB
PDGFRL
Tbio
Novelty:  0.0709225
p_int:  0.997647715
p_ni:  0.002247245
p_wrong:  0.00010504
Data Source:  BioPlex
FGF10
Tbio
Novelty:  0.00217451
p_int:  0.996760059
p_ni:  0.003239939
p_wrong:  2e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.996284773
p_ni:  0.003611355
p_wrong:  0.000103872
Data Source:  BioPlex
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.989613407
p_ni:  0.007775854
p_wrong:  0.002610739
Data Source:  BioPlex
UGGT2
Tbio
Family:  Enzyme
Novelty:  0.20635638
p_int:  0.985919584
p_ni:  0.01302424
p_wrong:  0.001056176
Score:  0.269
Data Source:  BioPlex,STRINGDB
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.981003555
p_ni:  0.006883759
p_wrong:  0.012112687
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
2
2
95.9
mean reticulocyte volume
1
1
1
38.8
late-onset Alzheimers disease
1
1
0
6.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
2
95.9
mean reticulocyte volume
1
38.8
late-onset Alzheimers disease
0
6.1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain 2
VGNC:7235
450291
Macaque
inter-alpha-trypsin inhibitor heavy chain 2
713575
Mouse
MGI:96619
16425
Rat
RGD:1565426
498793
Dog
inter-alpha-trypsin inhibitor heavy chain 2
VGNC:42146
478011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain 2
Macaque
inter-alpha-trypsin inhibitor heavy chain 2
Mouse
Rat
Dog
inter-alpha-trypsin inhibitor heavy chain 2
Publication Statistics
PubMed Score 19.95
PubMed score by year
PubTator Score 9.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title