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Tbio
ITGB8
Integrin beta-8

Protein Summary
Description
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072). It recognizes the sequence R-G-D in its ligands (PubMed:1918072). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; ho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222573
  • ENSP00000222573
  • ENSG00000105855
  • ENST00000537992
  • ENSP00000441561
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.93
gene perturbation
0.87
histone modification site profile
0.84
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.54   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.54   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999996842
p_ni:  0.000003152
p_wrong:  6e-9
Data Source:  BioPlex
ACTR3C
Tdark
Novelty:  0.16443513
p_int:  0.991724574
p_ni:  0.000020853
p_wrong:  0.008254573
Score:  0.236
Data Source:  BioPlex,STRINGDB
LMF1
Tbio
Family:  Enzyme
Novelty:  0.0280811
p_int:  0.98854967
p_ni:  0.01145033
Score:  0.622
Data Source:  BioPlex,STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
p_int:  0.889265867
p_ni:  0.110734133
Score:  0.571
Data Source:  BioPlex,STRINGDB
L2HGDH
Tbio
Family:  Enzyme
Novelty:  0.01766669
p_int:  0.872775376
p_ni:  0.127224624
Score:  0.188
Data Source:  BioPlex,STRINGDB
WRB
Tbio
Novelty:  0.01267171
p_int:  0.858312923
p_ni:  0.141582575
p_wrong:  0.000104502
Score:  0.314
Data Source:  BioPlex,STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.852723301
p_ni:  0.146721819
p_wrong:  0.000554881
Score:  0.19
Data Source:  BioPlex,STRINGDB
RHBDL1
Tdark
Family:  Enzyme
Novelty:  0.63616927
p_int:  0.83790173
p_ni:  0.162000162
p_wrong:  0.000098108
Score:  0.216
Data Source:  BioPlex,STRINGDB
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.823224437
p_ni:  0.176205781
p_wrong:  0.000569782
Score:  0.185
Data Source:  BioPlex,STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.996
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 5
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA4
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  9
more:  5 more common pathways
Pathways (25)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Integrin cell surface interactions
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
7
7
94.9
BMI-adjusted waist circumference
6
22
25
94.7
asthma
7
8
3
1.1
93.1
childhood onset asthma
2
3
0
1.1
90.3
heel bone mineral density
3
3
5
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
94.9
BMI-adjusted waist circumference
25
94.7
asthma
3
1.1
93.1
childhood onset asthma
0
1.1
90.3
heel bone mineral density
5
87.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 8
VGNC:4407
463282
Macaque
integrin subunit beta 8
707247
Mouse
MGI:1338035
320910
Rat
RGD:1311374
362800
Dog
integrin subunit beta 8
VGNC:42143
475253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 8
Macaque
integrin subunit beta 8
Mouse
Rat
Dog
integrin subunit beta 8
Publication Statistics
PubMed Score 79.54
PubMed score by year
PubTator Score 23.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title