Protein Summary
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin. This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling ...more
- ENST00000267082
- ENSP00000267082
- ENSG00000139626
- ENST00000422257
- ENSP00000408741
- ENST00000550743
- ENSP00000455374
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
PubMedID | 0.83 | ||
gene perturbation | 0.77 | ||
cell type or tissue | 0.71 | ||
cellular component | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.38 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 484 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.38 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 484 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (170)
Nearest Tclin Targets
Pathways (31)
Reactome (5)
KEGG (11)
PathwayCommons (8)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Immune System | ||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Reactome | Integrin cell surface interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Extracellular matrix organization | ||||
Immune System | ||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Integrin cell surface interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (5)
Components (8)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
spine bone mineral density | 1 | 1 | 1 | 57.8 | |||||
self reported educational attainment | 2 | 2 | 2 | 57.1 | |||||
mathematical ability | 2 | 2 | 2 | 45.6 | |||||
intelligence | 1 | 1 | 1 | 44.2 | |||||
1 | 1 | 1 | 44.2 | ||||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
spine bone mineral density | 1 | 57.8 | |||||
self reported educational attainment | 2 | 57.1 | |||||
mathematical ability | 2 | 45.6 | |||||
intelligence | 1 | 44.2 | |||||
1 | 44.2 | ||||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit beta 7 | VGNC:5437 | 451934 | |||||
Macaque | integrin subunit beta 7 | 699405 | ||||||
Mouse | MGI:96616 | 16421 | ||||||
Rat | RGD:2929 | 25713 | ||||||
Dog | integrin subunit beta 7 | VGNC:42142 | 477598 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit beta 7 | |||||
Macaque | integrin subunit beta 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit beta 7 | |||||
Publication Statistics
PubMed Score 65.38
PubMed score by year
PubTator Score 26.43
PubTator score by year
Related Publications
Text Mined References (69)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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