Protein Summary
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 s ...more
- ENST00000200181
- ENSP00000200181
- ENSG00000132470
- ENST00000449880
- ENSP00000400217
- ENST00000450894
- ENSP00000405536
- ENST00000579662
- ENSP00000463651
- CD104
- GP150
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
hub protein | 0.99 | ||
interacting protein | 0.91 | ||
biological term | 0.84 | ||
kinase | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 269.93 (req: < 5)
Gene RIFs: 150 (req: <= 3)
Antibodies: 967 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 269.93 (req: >= 5)
Gene RIFs: 150 (req: > 3)
Antibodies: 967 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (171)
ITGA6
Novelty: 0.00217985
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.999999529
p_ni: 2.92e-7
p_wrong: 1.79e-7
Data Source: BioPlex
Nearest Tclin Targets (11)
Upstream (5)
Downstream (6)
1 – 5 of 5
Pathways (38)
Reactome (9)
KEGG (8)
PathwayCommons (10)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Cell junction organization | ||||
Cell-Cell communication | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (2)
Components (9)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 93.3 | |||||
low density lipoprotein cholesterol measurement | 5 | 3 | 5 | 89.7 | |||||
eosinophil count | 3 | 2 | 3 | 79 | |||||
mean platelet volume | 1 | 1 | 1 | 72.3 | |||||
red blood cell distribution width | 2 | 2 | 2 | 70.4 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 93.3 | |||||
low density lipoprotein cholesterol measurement | 5 | 89.7 | |||||
eosinophil count | 3 | 79 | |||||
mean platelet volume | 1 | 72.3 | |||||
red blood cell distribution width | 2 | 70.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit beta 4 | VGNC:9339 | 454887 | |||||
Mouse | MGI:96613 | 192897 | ||||||
Rat | RGD:2928 | 25724 | ||||||
Horse | integrin subunit beta 4 | VGNC:19178 | 100051679 | |||||
Cow | integrin subunit beta 4 | VGNC:30329 | 506995 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit beta 4 | |||||
Mouse | ||||||
Rat | ||||||
Horse | integrin subunit beta 4 | |||||
Cow | integrin subunit beta 4 | |||||
Publication Statistics
PubMed Score 269.93
PubMed score by year
PubTator Score 141.02
PubTator score by year
Related Publications
Text Mined References (220)
GeneRif Annotations (150)
Items per page:
0 of 0
PMID | Year | Title |
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