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Tbio
ITGB4
Integrin beta-4

Protein Summary
Description
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200181
  • ENSP00000200181
  • ENSG00000132470
  • ENST00000449880
  • ENSP00000400217
  • ENST00000450894
  • ENSP00000405536
  • ENST00000579662
  • ENSP00000463651

Symbol
  • CD104
  • GP150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
hub protein
0.99
interacting protein
0.91
biological term
0.84
kinase
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.93   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 967   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.93   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 967   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (171)
ITGA6
Tbio
Novelty:  0.00217985
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.999999529
p_ni:  2.92e-7
p_wrong:  1.79e-7
Data Source:  BioPlex
PLEC
Tbio
Novelty:  0.00223244
Score:  0.999
Data Source:  Reactome,STRINGDB
COL17A1
Tbio
Novelty:  0.00141446
Score:  0.979
Data Source:  Reactome,STRINGDB
LAMB3
Tbio
Novelty:  0.00717673
Score:  0.979
Data Source:  Reactome,STRINGDB
DST
Tbio
Novelty:  0.00238839
Score:  0.976
Data Source:  Reactome,STRINGDB
ITGA3
Tchem
Novelty:  0.00505981
Score:  0.972
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.97
Data Source:  STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.967
Data Source:  STRINGDB
CD151
Tbio
Novelty:  0.00295527
Score:  0.964
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 5
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA4
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
Pathways (38)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Cell junction organization
Cell-Cell communication
Collagen formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
93.3
low density lipoprotein cholesterol measurement
5
3
5
89.7
eosinophil count
3
2
3
79
mean platelet volume
1
1
1
72.3
red blood cell distribution width
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
93.3
low density lipoprotein cholesterol measurement
5
89.7
eosinophil count
3
79
mean platelet volume
1
72.3
red blood cell distribution width
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 4
VGNC:9339
454887
Mouse
MGI:96613
192897
Rat
RGD:2928
25724
Horse
integrin subunit beta 4
VGNC:19178
100051679
Cow
integrin subunit beta 4
VGNC:30329
506995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 4
Mouse
Rat
Horse
integrin subunit beta 4
Cow
integrin subunit beta 4
Publication Statistics
PubMed Score 269.93
PubMed score by year
PubTator Score 141.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title