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Tbio
ITGB3BP
Centromere protein R

Protein Summary
Description
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271002
  • ENSP00000271002
  • ENSG00000142856
  • ENST00000371092
  • ENSP00000360133
  • ENST00000489099
  • ENSP00000432904

Symbol
  • CENPR
  • NRIF3
  • CENPR
  • NRIF3
  • TAP20
  • CENP-R
  • HSU37139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
virus perturbation
0.9
transcription factor binding site profile
0.79
biological process
0.71
gene perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.41   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.41   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
CENPP
Tbio
Novelty:  0.29282259
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
CENPO
Tbio
Novelty:  0.12059767
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
CENPU
Tbio
Novelty:  0.03681625
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
CENPQ
Tbio
Novelty:  0.19972678
p_int:  0.999998314
p_ni:  0.000001684
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.998546249
p_ni:  0.000776552
p_wrong:  0.000677199
Score:  0.538
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.994225039
p_ni:  0.004935921
p_wrong:  0.000839041
Data Source:  BioPlex
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.970029511
p_ni:  0.028692585
p_wrong:  0.001277904
Data Source:  BioPlex
CENPN
Tbio
Novelty:  0.06923443
Score:  0.993
Data Source:  STRINGDB
CENPT
Tbio
Novelty:  0.03878936
Score:  0.992
Data Source:  STRINGDB
CENPI
Tbio
Novelty:  0.01938121
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
2
2
1.1
80.4
type 1 diabetes mellitus
1
1
0
1.2
68.7
serum gamma-glutamyl transferase measurement
2
2
2
54.3
mean corpuscular volume
1
1
1
45
mean reticulocyte volume
1
1
1
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.1
80.4
type 1 diabetes mellitus
0
1.2
68.7
serum gamma-glutamyl transferase measurement
2
54.3
mean corpuscular volume
1
45
mean reticulocyte volume
1
25.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 3 binding protein
VGNC:6891
742958
Macaque
integrin subunit beta 3 binding protein
699279
Mouse
MGI:1914983
67733
Rat
RGD:1310044
362548
Dog
integrin subunit beta 3 binding protein
VGNC:53418
609967
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 3 binding protein
Macaque
integrin subunit beta 3 binding protein
Mouse
Rat
Dog
integrin subunit beta 3 binding protein
Publication Statistics
PubMed Score 23.41
PubMed score by year
PubTator Score 14.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title