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Tclin
ITGB3
Integrin beta-3

Protein Summary
Description
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000559488
  • ENSP00000452786
  • ENSG00000259207

Symbol
  • GP3A
  • GT
  • CD61
  • GP3A
  • BDPLT2
  • GPIIIa
  • BDPLT16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.96
protein domain
0.92
disease
0.85
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1393.31   (req: < 5)
Gene RIFs: 739   (req: <= 3)
Antibodies: 2118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1393.31   (req: >= 5)
Gene RIFs: 739   (req: > 3)
Antibodies: 2118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (354)
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.999
Data Source:  Reactome,STRINGDB
ITGA2B
Tclin
Novelty:  0.00023168
Score:  0.999
Data Source:  Reactome,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.997
Data Source:  Reactome,STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.994
Data Source:  Reactome,STRINGDB
FLNA
Tbio
Novelty:  0.00156479
Score:  0.992
Data Source:  STRINGDB
TLN1
Tbio
Novelty:  0.00803981
Score:  0.99
Data Source:  Reactome,STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.987
Data Source:  STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.985
Data Source:  STRINGDB
ITGA4
Tclin
Novelty:  0.00197607
Score:  0.985
Data Source:  STRINGDB
ITGA3
Tchem
Novelty:  0.00505981
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (96)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (69)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
3
5
90.7
total cholesterol measurement
3
2
4
86.2
BMI-adjusted hip circumference
1
4
4
75.8
apolipoprotein B measurement
1
1
1
68.8
platelet count
1
1
1
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
90.7
total cholesterol measurement
4
86.2
BMI-adjusted hip circumference
4
75.8
apolipoprotein B measurement
1
68.8
platelet count
1
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrin subunit beta 3
717379
Mouse
MGI:96612
16416
Rat
RGD:628868
29302
Dog
integrin subunit beta 3
403788
Horse
integrin subunit beta 3
100009709
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrin subunit beta 3
Mouse
Rat
Dog
integrin subunit beta 3
Horse
integrin subunit beta 3
Publication Statistics
PubMed Score 1393.31
PubMed score by year
PubTator Score 861.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title