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Tclin
ITGB2
Integrin beta-2

Protein Summary
Description
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302347
  • ENSP00000303242
  • ENSG00000160255
  • ENST00000355153
  • ENSP00000347279
  • ENST00000397850
  • ENSP00000380948
  • ENST00000397852
  • ENSP00000380950
  • ENST00000397857
  • ENSP00000380955

Symbol
  • CD18
  • MFI7
  • LAD
  • CD18
  • MF17
  • MFI7
  • LCAMB
  • LFA-1
  • MAC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
protein domain
0.92
disease
0.89
kinase perturbation
0.84
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: < 5)
Gene RIFs: 347   (req: <= 3)
Antibodies: 1847   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 495.28   (req: >= 5)
Gene RIFs: 347   (req: > 3)
Antibodies: 1847   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (463)
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
p_int:  0.999547608
p_ni:  0.000452392
Data Source:  BioPlex
CD151
Tbio
Novelty:  0.00295527
p_int:  0.998628095
p_ni:  0.00079667
p_wrong:  0.000575236
Data Source:  BioPlex
SCARF2
Tbio
Novelty:  0.08833851
p_int:  0.998307812
p_ni:  0.001669338
p_wrong:  0.00002285
Data Source:  BioPlex
OSTC
Tbio
Family:  Enzyme
Novelty:  0.06699106
p_int:  0.928050967
p_ni:  0.063649418
p_wrong:  0.008299615
Data Source:  BioPlex
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.868402109
p_ni:  0.131597891
Data Source:  BioPlex
MAD2L2
Tbio
Novelty:  0.01091072
p_int:  0.854743113
p_ni:  0.059398347
p_wrong:  0.08585854
Data Source:  BioPlex
CGRRF1
Tdark
Novelty:  0.49690187
p_int:  0.84739799
p_ni:  0.007127491
p_wrong:  0.145474519
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.844417231
p_ni:  0.138507542
p_wrong:  0.017075227
Data Source:  BioPlex
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.999
Data Source:  Reactome,STRINGDB
ITGAX
Tbio
Novelty:  0.00040471
Score:  0.997
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Extracellular matrix organization
Hemostasis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (68)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Non-traceable Author Statement (NAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
3
4
92.3
red blood cell distribution width
3
2
3
86
mean corpuscular hemoglobin concentration
1
1
1
85.4
mean reticulocyte volume
1
1
1
81.9
apolipoprotein A 1 measurement
1
1
1
78.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
92.3
red blood cell distribution width
3
86
mean corpuscular hemoglobin concentration
1
85.4
mean reticulocyte volume
1
81.9
apolipoprotein A 1 measurement
1
78.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 2
VGNC:3734
458607
Macaque
integrin subunit beta 2
710577
Mouse
MGI:96611
16414
Rat
RGD:1305581
309684
Dog
integrin subunit beta 2
VGNC:42139
403770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 2
Macaque
integrin subunit beta 2
Mouse
Rat
Dog
integrin subunit beta 2
Publication Statistics
PubMed Score 495.28
PubMed score by year
PubTator Score 1222.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title