Protein Summary
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytot ...more
- ENST00000302278
- ENSP00000303351
- ENSG00000150093
- ENST00000396033
- ENSP00000379350
- ENST00000423113
- ENSP00000388694
- FNRB
- MDF2
- MSK12
- CD29
- FNRB
- MDF2
- VLAB
- GPIIA
- MSK12
- VLA-BETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
disease perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.98 | ||
protein domain | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1618.91 (req: < 5)
Gene RIFs: 895 (req: <= 3)
Antibodies: 2611 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1618.91 (req: >= 5)
Gene RIFs: 895 (req: > 3)
Antibodies: 2611 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 61
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (472)
ITGA6
Novelty: 0.00217985
p_int: 0.999925123
p_ni: 0.000074878
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
ITGA9
Novelty: 0.01488635
p_int: 0.994906846
p_ni: 0.005093154
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.969144703
p_ni: 0.030855296
Score: 0.469
Data Source: BioPlex,STRINGDB
TSPAN11
Novelty: 0.37247094
p_int: 0.857073632
p_ni: 0.142926368
Score: 0.206
Data Source: BioPlex,STRINGDB
TNFSF13B
Novelty: 0.00069885
p_int: 0.807904863
p_ni: 0.192095137
Score: 0.254
Data Source: BioPlex,STRINGDB
CDS1
Family: Enzyme
Novelty: 0.08094799
p_int: 0.778495835
p_ni: 0.221504165
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (111)
Reactome (39)
KEGG (25)
PathwayCommons (26)
WikiPathways (21)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Axon guidance | ||||
Reactome | Basigin interactions | ||||
Reactome | CHL1 interactions | ||||
Reactome | Cell junction organization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Axon guidance | ||||
Basigin interactions | ||||
CHL1 interactions | ||||
Cell junction organization | ||||
Viral Interactions (0)
Gene Ontology Terms (96)
Functions (13)
Components (35)
Processes (48)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit beta 1 | VGNC:4717 | 450396 | |||||
Macaque | integrin subunit beta 1 | 574312 | ||||||
Mouse | MGI:96610 | 16412 | ||||||
Rat | RGD:2927 | 24511 | ||||||
Dog | integrin subunit beta 1 | VGNC:42136 | 477956 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | integrin subunit beta 1 | |||||
Macaque | integrin subunit beta 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit beta 1 | |||||
Publication Statistics
PubMed Score 1618.91
PubMed score by year
PubTator Score 1551.50
PubTator score by year
Related Publications
Text Mined References (1127)
GeneRif Annotations (895)
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