You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ITGB1
Integrin beta-1

Protein Summary
Description
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302278
  • ENSP00000303351
  • ENSG00000150093
  • ENST00000396033
  • ENSP00000379350
  • ENST00000423113
  • ENSP00000388694

Symbol
  • FNRB
  • MDF2
  • MSK12
  • CD29
  • FNRB
  • MDF2
  • VLAB
  • GPIIA
  • MSK12
  • VLA-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
interacting protein
0.99
molecular function
0.98
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.91   (req: < 5)
Gene RIFs: 895   (req: <= 3)
Antibodies: 2611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.91   (req: >= 5)
Gene RIFs: 895   (req: > 3)
Antibodies: 2611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (472)
ITGA6
Tbio
Novelty:  0.00217985
p_int:  0.999925123
p_ni:  0.000074878
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
ITGA9
Tbio
Novelty:  0.01488635
p_int:  0.994906846
p_ni:  0.005093154
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.969144703
p_ni:  0.030855296
Score:  0.469
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.890877511
p_ni:  0.109122489
Data Source:  BioPlex
TSPAN11
Tdark
Novelty:  0.37247094
p_int:  0.857073632
p_ni:  0.142926368
Score:  0.206
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.832333931
p_ni:  0.167666069
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.807904863
p_ni:  0.192095137
Score:  0.254
Data Source:  BioPlex,STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
p_int:  0.778495835
p_ni:  0.221504165
Score:  0.189
Data Source:  BioPlex,STRINGDB
ITGA5
Tbio
Novelty:  0.00285802
Score:  0.999
Data Source:  Reactome,STRINGDB
ITGAV
Tchem
Novelty:  0.00148589
Score:  0.994
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Basigin interactions
Reactome
CHL1 interactions
Reactome
Cell junction organization
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Basigin interactions
CHL1 interactions
Cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (96)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 1
VGNC:4717
450396
Macaque
integrin subunit beta 1
574312
Mouse
MGI:96610
16412
Rat
RGD:2927
24511
Dog
integrin subunit beta 1
VGNC:42136
477956
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit beta 1
Macaque
integrin subunit beta 1
Mouse
Rat
Dog
integrin subunit beta 1
Publication Statistics
PubMed Score 1618.91
PubMed score by year
PubTator Score 1551.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title