Tclin ITGB1 Integrin beta-1

Protein Summary

Description

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). Isoform 5: Isoform 5 displaces isoform 1 in striated muscles. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5. (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus. (Microbial infection) Acts as a receptor for Mammalian reovirus. (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05556
• A8K6N2
• D3DRX9
• D3DRY3
• D3DRY4
• D3DRY5
• P78466
• P78467
• Q13089
• Q13090
• Q13091
• Q13212
• Q14622
• Q14647
• Q29RW2
• Q7Z3V1
• Q8WUM6

Gene Name

• ITGB1

Ensembl ID

• ENST00000302278
• ENSP00000303351
• ENSG00000150093
• ENST00000396033
• ENSP00000379350
• ENST00000423113
• ENSP00000388694

Symbol

• FNRB
• MDF2
• MSK12
• CD29
• FNRB
• MDF2
• VLAB
• GPIIA
• MSK12
• VLA-BETA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	1
interacting protein	0.99
molecular function	0.98
protein domain	0.97

Protein Classes

PANTHER Classes

Protein / Receptor / Integrin Beta-1

Protein / Cell Adhesion Molecule / Integrin Beta-1

DTO Classes

Protein / Receptor / Integrin Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.91   (req: < 5)

Gene RIFs: 895   (req: <= 3)

Antibodies: 2611   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1618.91   (req: >= 5)

Gene RIFs: 895   (req: > 3)

Antibodies: 2611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

natalizumab

ITGB1Tclin

ANTIBODY BINDING :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (472)

Explore Interacting Targets

1 – 10 of 472

• See Interactions on String-DB

ITGA6

Tbio

Novelty:  0.00217985

p_int:  0.999925123

p_ni:  0.000074878

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

ITGA9

Tbio

Novelty:  0.01488635

p_int:  0.994906846

p_ni:  0.005093154

Score:  0.989

Data Source:  BioPlex,Reactome,STRINGDB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.969144703

p_ni:  0.030855296

Score:  0.469

Data Source:  BioPlex,STRINGDB

FAM19A4

Tbio

Novelty:  0.04305684

p_int:  0.890877511

p_ni:  0.109122489

Data Source:  BioPlex

TSPAN11

Tdark

Novelty:  0.37247094

p_int:  0.857073632

p_ni:  0.142926368

Score:  0.206

Data Source:  BioPlex,STRINGDB

LGALS9

Tchem

Novelty:  0.00381766

p_int:  0.832333931

p_ni:  0.167666069

Data Source:  BioPlex

TNFSF13B

Tclin

Novelty:  0.00069885

p_int:  0.807904863

p_ni:  0.192095137

Score:  0.254

Data Source:  BioPlex,STRINGDB

CDS1

Tbio

Family:  Enzyme

Novelty:  0.08094799

p_int:  0.778495835

p_ni:  0.221504165

Score:  0.189

Data Source:  BioPlex,STRINGDB

ITGA5

Tbio

Novelty:  0.00285802

Score:  0.999

Data Source:  Reactome,STRINGDB

ITGAV

Tchem

Novelty:  0.00148589

Score:  0.994

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (111)

Reactome (39)

KEGG (25)

PathwayCommons (26)

WikiPathways (21)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Basigin interactions	25 targets	R-HSA-210991
Reactome	CHL1 interactions	9 targets	R-HSA-447041
Reactome	Cell junction organization	88 targets	R-HSA-446728

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Axon guidance	533 targets	R-HSA-422475
Basigin interactions	25 targets	R-HSA-210991
CHL1 interactions	9 targets	R-HSA-447041
Cell junction organization	88 targets	R-HSA-446728

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (96)

Functions (13)

Components (35)

Processes (48)

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1 – 10 of 13

GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
cell adhesion molecule binding	Inferred from Physical Interaction (IPI)	UniProtKB
fibronectin binding	Inferred from Physical Interaction (IPI)	UniProtKB
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein-containing complex binding	Inferred from Physical Interaction (IPI)	UniProtKB
collagen binding involved in cell-matrix adhesion	Inferred from Mutant Phenotype (IMP)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
integrin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
coreceptor activity	Traceable Author Statement (TAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit beta 1	VGNC:4717	450396
Macaque	integrin subunit beta 1		574312
Mouse	integrin beta 1 (fibronectin receptor beta)	MGI:96610	16412
Rat	integrin subunit beta 1	RGD:2927	24511
Dog	integrin subunit beta 1	VGNC:42136	477956

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit beta 1
Macaque	integrin subunit beta 1
Mouse	integrin beta 1 (fibronectin receptor beta)
Rat	integrin subunit beta 1
Dog	integrin subunit beta 1

Publication Statistics

PubMed Score 1618.91

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PubTator Score 1551.50

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Related Publications

Text Mined References (1127)

GeneRif Annotations (895)

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PMID	Year	Title