Protein Summary
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
- ENST00000268296
- ENSP00000268296
- ENSG00000140678
- CD11C
- CD11C
- SLEB6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.93 | ||
protein domain | 0.85 | ||
biological term | 0.69 | ||
cell type or tissue | 0.64 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2230.33 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 2147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2230.33 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 2147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (459)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (23)
Reactome (11)
KEGG (3)
PathwayCommons (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Cytokine Signaling in Immune system | ||||
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
12 | 7 | 0 | 1.7 | 98.9 | |||||
2 | 3 | 0 | 1.2 | 84.4 | |||||
body mass index | 1 | 1 | 1 | 70 | |||||
Glycosuria | 4 | 2 | 0 | 1.3 | 68.4 | ||||
red blood cell distribution width | 4 | 1 | 4 | 47.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.7 | 98.9 | |||||
0 | 1.2 | 84.4 | |||||
body mass index | 1 | 70 | |||||
Glycosuria | 0 | 1.3 | 68.4 | ||||
red blood cell distribution width | 4 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha X | VGNC:5827 | 454070 | |||||
Mouse | MGI:96609 | 16411 | ||||||
Rat | RGD:1561123 | 499271 | ||||||
Dog | integrin subunit alpha X | VGNC:42135 | 489929 | |||||
Horse | integrin subunit alpha X | VGNC:51160 | 100064779 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha X | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha X | |||||
Horse | integrin subunit alpha X | |||||
Publication Statistics
PubMed Score 2230.33
PubMed score by year
PubTator Score 673.77
PubTator score by year
Related Publications
Text Mined References (100)
GeneRif Annotations (68)
Items per page:
0 of 0
PMID | Year | Title |
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