Protein Summary
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta ...more
- ENST00000356798
- ENSP00000349252
- ENSG00000005844
- ENST00000358164
- ENSP00000350886
- CD11A
- CD11A
- LFA-1
- LFA1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
biological process | 0.8 | ||
cellular component | 0.72 | ||
tissue sample | 0.71 | ||
disease | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 907.48 (req: < 5)
Gene RIFs: 123 (req: <= 3)
Antibodies: 1879 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 907.48 (req: >= 5)
Gene RIFs: 123 (req: > 3)
Antibodies: 1879 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 73
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (73)
Protein-Protein Interactions (297)
Nearest Tclin Targets
Pathways (42)
Reactome (14)
KEGG (11)
PathwayCommons (5)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Cell surface interactions at the vascular wall | ||||
Extracellular matrix organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (5)
Components (7)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
myeloid white cell count | 2 | 2 | 2 | 94.8 | |||||
lymphocyte count | 3 | 2 | 3 | 91.1 | |||||
leukocyte count | 2 | 2 | 2 | 90 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 85.7 | |||||
neutrophil count | 2 | 2 | 2 | 82.3 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
myeloid white cell count | 2 | 94.8 | |||||
lymphocyte count | 3 | 91.1 | |||||
leukocyte count | 2 | 90 | |||||
lymphocyte percentage of leukocytes | 2 | 85.7 | |||||
neutrophil count | 2 | 82.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha L | VGNC:13720 | 454045 | |||||
Macaque | integrin subunit alpha L | 711945 | ||||||
Mouse | MGI:96606 | 16408 | ||||||
Rat | RGD:631424 | 308995 | ||||||
Dog | integrin subunit alpha L | VGNC:42132 | 489905 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha L | |||||
Macaque | integrin subunit alpha L | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha L | |||||
Publication Statistics
PubMed Score 907.48
PubMed score by year
PubTator Score 1481.84
PubTator score by year
Related Publications
Text Mined References (166)
GeneRif Annotations (123)
Items per page:
0 of 0
PMID | Year | Title |
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