Tbio ITGA8 Integrin alpha-8

Protein Summary

Description

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P53708
• B0YJ31
• Q5VX94

Gene Name

• ITGA8

Ensembl ID

• ENST00000378076
• ENSP00000367316
• ENSG00000077943

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.86
biological process	0.73
protein domain	0.73
virus perturbation	0.72
gene perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.93   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.93   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (137)

Explore Interacting Targets

1 – 10 of 137

• See Interactions on String-DB

SUSD4

Tbio

Novelty:  0.22201938

p_int:  0.999557171

p_ni:  0.000442678

p_wrong:  1.5e-7

Data Source:  BioPlex

BTNL8

Tdark

Novelty:  0.40339869

p_int:  0.998723122

p_ni:  0.001276877

p_wrong:  1e-9

Data Source:  BioPlex

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.998541494

p_ni:  0.001458506

Data Source:  BioPlex

TAZ

Tbio

Novelty:  0.00372301

p_int:  0.997808871

p_ni:  0.002191111

p_wrong:  1.8e-8

Data Source:  BioPlex

DKKL1

Tbio

Novelty:  0.00544618

p_int:  0.997492574

p_ni:  0.002507236

p_wrong:  1.9e-7

Data Source:  BioPlex

CLU

Tbio

Novelty:  0.00054776

p_int:  0.997451574

p_ni:  0.00254841

p_wrong:  1.6e-8

Data Source:  BioPlex

PTPRK

Tbio

Family:  Enzyme

Novelty:  0.03149943

p_int:  0.997003637

p_ni:  0.002996324

p_wrong:  4e-8

Score:  0.206

Data Source:  BioPlex,STRINGDB

ADAM18

Tdark

Family:  Enzyme

Novelty:  0.22622379

p_int:  0.988775564

p_ni:  0.011224354

p_wrong:  8.2e-8

Data Source:  BioPlex

BST1

Tbio

Family:  Enzyme

Novelty:  0.01329061

p_int:  0.984758111

p_ni:  0.015241885

p_wrong:  3e-9

Data Source:  BioPlex

PNLIPRP1

Tbio

Family:  Enzyme

Novelty:  0.04756238

p_int:  0.975402814

p_ni:  0.024153881

p_wrong:  0.000443305

Data Source:  BioPlex

Nearest Tclin Targets (11)

Explore Nearest Tclin Targets

Upstream (5)

Downstream (6)

1 – 5 of 5

ITGB1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

ITGA2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  8

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  4 more common pathways

ITGA4

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

ITGB3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  8

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  4 more common pathways

ITGB7

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

Pathways (26)

Reactome (5)

KEGG (9)

PathwayCommons (6)

WikiPathways (6)

ECM proteoglycans (R-HSA-3000178)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178
Reactome	Elastic fibre formation	41 targets	R-HSA-1566948
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Integrin cell surface interactions	66 targets	R-HSA-216083
Reactome	Molecules associated with elastic fibres	30 targets	R-HSA-2129379

Name	Explore in Pharos	Explore in Source
ECM proteoglycans	56 targets	R-HSA-3000178
Elastic fibre formation	41 targets	R-HSA-1566948
Extracellular matrix organization	297 targets	R-HSA-1474244
Integrin cell surface interactions	66 targets	R-HSA-216083
Molecules associated with elastic fibres	30 targets	R-HSA-2129379

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (27)

Functions (1)

Components (10)

Processes (16)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1	1	1		49.5
Parkinson's disease	EFO_0002508	1	1	0	1.1	24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1		49.5
Parkinson's disease	EFO_0002508	0	1.1	24.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
mean reticulocyte volume
Parkinson's disease

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
hearing/vestibular/ear phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype
respiratory system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 8	VGNC:12349	450323
Macaque	integrin subunit alpha 8		698888
Mouse	integrin alpha 8	MGI:109442	241226
Rat	integrin subunit alpha 8	RGD:621634	364786
Dog	integrin subunit alpha 8	VGNC:42130	487119

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 8
Macaque	integrin subunit alpha 8
Mouse	integrin alpha 8
Rat	integrin subunit alpha 8
Dog	integrin subunit alpha 8

Publication Statistics

PubMed Score 45.93

PubMed score by year

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PubTator Score 15.61

PubTator score by year

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Related Publications

Text Mined References (32)

GeneRif Annotations (16)

Items per page:

10

0 of 0

PMID	Year	Title