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Tbio
ITGA7
Integrin alpha-7

Protein Summary
Description
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257879
  • ENSP00000257879
  • ENSG00000135424
  • ENST00000452168
  • ENSP00000393844
  • ENST00000553804
  • ENSP00000452120
  • ENST00000555728
  • ENSP00000452387
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.89
cellular component
0.79
gene perturbation
0.74
protein domain
0.73
cell type or tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.89   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.89   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
TSPAN11
Tdark
Novelty:  0.37247094
p_int:  0.999800575
p_ni:  0.000199425
Score:  0.282
Data Source:  BioPlex,STRINGDB
SUSD4
Tbio
Novelty:  0.22201938
p_int:  0.999257032
p_ni:  0.000742968
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.999081442
p_ni:  0.000918558
Data Source:  BioPlex
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.995787159
p_ni:  0.004212839
p_wrong:  2e-9
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.994101359
p_ni:  0.005898641
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.993660827
p_ni:  0.006339171
p_wrong:  2e-9
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.993226156
p_ni:  0.006773844
p_wrong:  1e-9
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.977412278
p_ni:  0.022587554
p_wrong:  1.67e-7
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.970248928
p_ni:  0.029751055
p_wrong:  1.7e-8
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.958284858
p_ni:  0.041713011
p_wrong:  0.000002131
Data Source:  BioPlex
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 5
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA4
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGA2B
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB1
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
ITGB3
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  8
more:  4 more common pathways
Pathways (43)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Laminin interactions
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Integrin cell surface interactions
Laminin interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
3
3
13.8
98.1
Myopia
3
2
0
1.3
95.9
age at onset
1
1
0
13.8
87.2
Abnormality of refraction
1
1
1
75.9
atrophic macular degeneration
1
1
0
1.2
50.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error
3
13.8
98.1
Myopia
0
1.3
95.9
age at onset
0
13.8
87.2
Abnormality of refraction
1
75.9
atrophic macular degeneration
0
1.2
50.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 7
VGNC:5436
451967
Mouse
MGI:102700
16404
Rat
RGD:71022
81008
Dog
integrin subunit alpha 7
VGNC:42129
481097
Horse
integrin subunit alpha 7
VGNC:19168
100058756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 7
Mouse
Rat
Dog
integrin subunit alpha 7
Horse
integrin subunit alpha 7
Publication Statistics
PubMed Score 100.89
PubMed score by year
PubTator Score 33.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title