Protein Summary
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that compr ...more
- ENST00000264107
- ENSP00000264107
- ENSG00000091409
- ENST00000409080
- ENSP00000386896
- ENST00000409532
- ENSP00000386614
- ENST00000442250
- ENSP00000406694
- ENST00000458358
- ENSP00000394169
- CD49f
- VLA-6
- ITGA6B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.95 | ||
gene perturbation | 0.91 | ||
biological process | 0.89 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.15 (req: < 5)
Gene RIFs: 175 (req: <= 3)
Antibodies: 1213 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 450.15 (req: >= 5)
Gene RIFs: 175 (req: > 3)
Antibodies: 1213 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (262)
ITGB4
Novelty: 0.00386461
p_int: 0.999999966
p_ni: 3.4e-8
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
TSPAN11
Novelty: 0.37247094
p_int: 0.999972664
p_ni: 0.000027336
Score: 0.211
Data Source: BioPlex,STRINGDB
ITGB1
Novelty: 0.00055626
p_int: 0.999925123
p_ni: 0.000074878
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
CD151
Novelty: 0.00295527
p_int: 0.999922571
p_ni: 0.000077377
p_wrong: 5.3e-8
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.999871775
p_ni: 0.000128224
p_wrong: 1e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
BTNL8
Novelty: 0.40339869
p_int: 0.998837263
p_ni: 0.001162735
p_wrong: 2e-9
Data Source: BioPlex
B4GALT4
Family: Enzyme
Novelty: 0.11226614
p_int: 0.998447101
p_ni: 0.001552899
Score: 0.205
Data Source: BioPlex,STRINGDB
PSCA
Novelty: 0.00323778
p_int: 0.990193613
p_ni: 0.009806387
Score: 0.212
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (11)
Upstream (5)
Downstream (6)
1 – 5 of 5
Pathways (47)
Reactome (13)
KEGG (13)
PathwayCommons (10)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Basigin interactions | ||||
Reactome | Cell junction organization | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Cell-Cell communication | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Basigin interactions | ||||
Cell junction organization | ||||
Cell surface interactions at the vascular wall | ||||
Cell-Cell communication | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (6)
Components (10)
Processes (26)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 3 | 0 | 1.3 | 94.9 | |||||
mean platelet volume | 2 | 1 | 2 | 12.8 | |||||
electrocardiography | 1 | 1 | 1 | 1.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.3 | 94.9 | |||||
mean platelet volume | 2 | 12.8 | |||||
electrocardiography | 1 | 1.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 6 | VGNC:2705 | 459742 | |||||
Macaque | integrin subunit alpha 6 | 697643 | ||||||
Mouse | MGI:96605 | 16403 | ||||||
Rat | RGD:621633 | 114517 | ||||||
Dog | integrin subunit alpha 6 | VGNC:42128 | 100856563 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 6 | |||||
Macaque | integrin subunit alpha 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha 6 | |||||
Publication Statistics
PubMed Score 450.15
PubMed score by year
PubTator Score 238.26
PubTator score by year
Related Publications
Text Mined References (249)
GeneRif Annotations (175)
Items per page:
0 of 0
PMID | Year | Title |
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