Tbio ITGA6 Integrin alpha-6

Protein Summary

Description

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P23229
• B2RMU9
• B4DG69
• B4DKB8
• C4AM96
• G5E9H1
• Q08443
• Q0MRC7
• Q14646
• Q16508
• Q53RX7
• Q59HB7
• Q86VL6
• Q9UCT1
• Q9UN03

Gene Name

• ITGA6

Ensembl ID

• ENST00000264107
• ENSP00000264107
• ENSG00000091409
• ENST00000409080
• ENSP00000386896
• ENST00000409532
• ENSP00000386614
• ENST00000442250
• ENSP00000406694
• ENST00000458358
• ENSP00000394169

Symbol

• CD49f
• VLA-6
• ITGA6B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.95
gene perturbation	0.91
biological process	0.89
cellular component	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.15   (req: < 5)

Gene RIFs: 175   (req: <= 3)

Antibodies: 1213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.15   (req: >= 5)

Gene RIFs: 175   (req: > 3)

Antibodies: 1213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (262)

Explore Interacting Targets

1 – 10 of 262

• See Interactions on String-DB

ITGB4

Tbio

Novelty:  0.00386461

p_int:  0.999999966

p_ni:  3.4e-8

Score:  0.988

Data Source:  BioPlex,Reactome,STRINGDB

TSPAN11

Tdark

Novelty:  0.37247094

p_int:  0.999972664

p_ni:  0.000027336

Score:  0.211

Data Source:  BioPlex,STRINGDB

ITGB1

Tclin

Novelty:  0.00055626

p_int:  0.999925123

p_ni:  0.000074878

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

CD151

Tbio

Novelty:  0.00295527

p_int:  0.999922571

p_ni:  0.000077377

p_wrong:  5.3e-8

Score:  0.966

Data Source:  BioPlex,Reactome,STRINGDB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.999871775

p_ni:  0.000128224

p_wrong:  1e-9

Score:  0.205

Data Source:  BioPlex,STRINGDB

RTN4

Tbio

Novelty:  0.00080371

p_int:  0.999691896

p_ni:  0.000308105

Data Source:  BioPlex

BTNL8

Tdark

Novelty:  0.40339869

p_int:  0.998837263

p_ni:  0.001162735

p_wrong:  2e-9

Data Source:  BioPlex

B4GALT4

Tbio

Family:  Enzyme

Novelty:  0.11226614

p_int:  0.998447101

p_ni:  0.001552899

Score:  0.205

Data Source:  BioPlex,STRINGDB

CD160

Tbio

Novelty:  0.01511748

p_int:  0.996322998

p_ni:  0.003677002

Data Source:  BioPlex

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.990193613

p_ni:  0.009806387

Score:  0.212

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (11)

Explore Nearest Tclin Targets

Upstream (5)

Downstream (6)

1 – 5 of 5

ITGB3

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  5 more common pathways

ITGA4

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  10

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  6 more common pathways

ITGB1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  12

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  8 more common pathways

ITGA2B

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  11

1: PI3K-Akt signaling pathway

2: ECM-receptor interaction

3: Focal adhesion

4: Dilated cardiomyopathy (DCM)

more:  7 more common pathways

ITGB7

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  9

1: PI3K-Akt signaling pathway

2: Cell adhesion molecules (CAMs)

3: ECM-receptor interaction

4: Focal adhesion

more:  5 more common pathways

Pathways (47)

Reactome (13)

KEGG (13)

PathwayCommons (10)

WikiPathways (11)

Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

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Items per page:

5

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Basigin interactions	25 targets	R-HSA-210991
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931

Name	Explore in Pharos	Explore in Source
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Basigin interactions	25 targets	R-HSA-210991
Cell junction organization	88 targets	R-HSA-446728
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Cell-Cell communication	121 targets	R-HSA-1500931

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (42)

Functions (6)

Components (10)

Processes (26)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
insulin-like growth factor I binding	Inferred from Direct Assay (IDA)	UniProtKB
neuregulin binding	Inferred from Direct Assay (IDA)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
laminin binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	6	3	0	1.3	94.9
mean platelet volume	EFO_0004584	2	1	2		12.8
electrocardiography	EFO_0004327	1	1	1		1.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	0	1.3	94.9
mean platelet volume	EFO_0004584	2		12.8
electrocardiography	EFO_0004327	1		1.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Epidermolysis bullosa
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
mean platelet volume
prostate carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
mortality/aging
neoplasm
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 6	VGNC:2705	459742
Macaque	integrin subunit alpha 6		697643
Mouse	integrin alpha 6	MGI:96605	16403
Rat	integrin subunit alpha 6	RGD:621633	114517
Dog	integrin subunit alpha 6	VGNC:42128	100856563

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha 6
Macaque	integrin subunit alpha 6
Mouse	integrin alpha 6
Rat	integrin subunit alpha 6
Dog	integrin subunit alpha 6

Publication Statistics

PubMed Score 450.15

PubMed score by year

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PubTator Score 238.26

PubTator score by year

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Related Publications

Text Mined References (249)

GeneRif Annotations (175)

Items per page:

10

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PMID	Year	Title