Protein Summary
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). The gene encodes a member of the integr ...more
- ENST00000339307
- ENSP00000340149
- ENSG00000115232
- ENST00000397033
- ENSP00000380227
- CD49D
- IA4
- CD49D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.94 | ||
interacting protein | 0.92 | ||
cellular component | 0.79 | ||
biological term | 0.77 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 419.14 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 1835 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 419.14 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 1835 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 128
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (128)
Protein-Protein Interactions (260)
LGALS8
Novelty: 0.00623836
p_int: 0.999347776
p_ni: 0.000652224
Score: 0.406
Data Source: BioPlex,STRINGDB
CST9
Novelty: 0.08129086
p_int: 0.998446921
p_ni: 0.001553079
Score: 0.237
Data Source: BioPlex,STRINGDB
BTNL8
Novelty: 0.40339869
p_int: 0.99581156
p_ni: 0.004187797
p_wrong: 6.43e-7
Data Source: BioPlex
LGALS9
Novelty: 0.00381766
p_int: 0.995172481
p_ni: 0.004827519
Score: 0.226
Data Source: BioPlex,STRINGDB
PTCH1
Novelty: 0.00077635
p_int: 0.99456638
p_ni: 0.005215166
p_wrong: 0.000218454
Data Source: BioPlex
PON2
Family: Enzyme
Novelty: 0.00414855
p_int: 0.983720088
p_ni: 0.016279912
Data Source: BioPlex
HYOU1
Novelty: 0.00833649
p_int: 0.979569996
p_ni: 0.020425941
p_wrong: 0.000004064
Data Source: BioPlex
FAM19A2
Novelty: 0.28999346
p_int: 0.974015755
p_ni: 0.023807286
p_wrong: 0.002176959
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00368876
p_int: 0.969295775
p_ni: 0.030703748
p_wrong: 4.77e-7
Data Source: BioPlex
PRSS2
Family: Enzyme
Novelty: 0.00959404
p_int: 0.957084011
p_ni: 0.042682596
p_wrong: 0.000233392
Score: 0.178
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (44)
Reactome (12)
KEGG (14)
PathwayCommons (10)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Cell surface interactions at the vascular wall | ||||
Extracellular matrix organization | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (36)
Functions (5)
Components (8)
Processes (23)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte count | 9 | 9 | 11 | 99.8 | |||||
monocyte percentage of leukocytes | 2 | 3 | 4 | 98.2 | |||||
leukocyte count | 5 | 4 | 5 | 95.8 | |||||
myeloid white cell count | 3 | 3 | 3 | 94.8 | |||||
reticulocyte measurement | 3 | 3 | 4 | 94.8 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte count | 11 | 99.8 | |||||
monocyte percentage of leukocytes | 4 | 98.2 | |||||
leukocyte count | 5 | 95.8 | |||||
myeloid white cell count | 3 | 94.8 | |||||
reticulocyte measurement | 4 | 94.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 4 | VGNC:2704 | 470596 | |||||
Macaque | integrin subunit alpha 4 | 704745 | ||||||
Mouse | MGI:96603 | 16401 | ||||||
Rat | RGD:1593249 | 311144 | ||||||
Dog | integrin subunit alpha 4 | VGNC:42126 | 488429 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | integrin subunit alpha 4 | |||||
Macaque | integrin subunit alpha 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha 4 | |||||
Publication Statistics
PubMed Score 419.14
PubMed score by year
PubTator Score 248.43
PubTator score by year
Related Publications
Text Mined References (230)
GeneRif Annotations (187)
Items per page:
0 of 0
PMID | Year | Title |
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