Tchem ITGA3 Integrin alpha-3

Protein Summary

Description

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P26006
• A7E246
• B7ZM80
• B9EGQ1
• D3DTX4
• D3DTX5

Gene Name

• ITGA3

Ensembl ID

• ENST00000007722
• ENSP00000007722
• ENSG00000005884
• ENST00000320031
• ENSP00000315190

Symbol

• MSK18
• VL3A
• CD49C
• FRP-2
• GAPB3
• ILNEB
• MSK18
• VCA-2
• VLA3a
• GAP-B3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.95
biological process	0.91
transcription factor perturbation	0.88
disease perturbation	0.79
cellular component	0.78

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.84   (req: < 5)

Gene RIFs: 151   (req: <= 3)

Antibodies: 933   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.84   (req: >= 5)

Gene RIFs: 151   (req: > 3)

Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0