Protein Summary
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure ...more
- ENST00000262407
- ENSP00000262407
- ENSG00000005961
- GP2B
- ITGAB
- GT
- GTA
- CD41
- GP2B
- HPA3
- CD41B
- GPIIb
- BDPLT2
- BDPLT16
- PPP1R93
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
protein complex | 0.94 | ||
disease | 0.82 | ||
cellular component | 0.74 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4309.5 (req: < 5)
Gene RIFs: 259 (req: <= 3)
Antibodies: 1685 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4309.5 (req: >= 5)
Gene RIFs: 259 (req: > 3)
Antibodies: 1685 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (0)
Protein-Protein Interactions (349)
Nearest Tclin Targets
Pathways (70)
Reactome (39)
KEGG (14)
PathwayCommons (8)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 3 | 4 | 96.4 | |||||
platelet count | 3 | 2 | 2 | 2.4 | 89.2 | ||||
progranulin measurement | 1 | 1 | 1 | 60.2 | |||||
platelet crit | 1 | 1 | 1 | 51.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 32.9 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 96.4 | |||||
platelet count | 2 | 2.4 | 89.2 | ||||
progranulin measurement | 1 | 60.2 | |||||
platelet crit | 1 | 51.7 | |||||
mean reticulocyte volume | 1 | 32.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | integrin subunit alpha 2b | 714955 | ||||||
Mouse | MGI:96601 | 16399 | ||||||
Rat | RGD:1596428 | 685269 | ||||||
Dog | integrin subunit alpha 2b | VGNC:42124 | 403789 | |||||
Horse | integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | integrin subunit alpha 2b | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha 2b | |||||
Horse | integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138] | |||||
Publication Statistics
PubMed Score 4309.50
PubMed score by year
PubTator Score 2643.78
PubTator score by year
Related Publications
Text Mined References (388)
GeneRif Annotations (259)
Items per page:
0 of 0
PMID | Year | Title |
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