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Tbio
ITFG2
KICSTOR complex protein ITFG2

Protein Summary
Description
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228799
  • ENSP00000228799
  • ENSG00000111203
  • ENST00000540929
  • ENSP00000443329
  • ENST00000644517
  • ENSP00000496068

Symbol
  • FGGAP1
  • MDS028
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
cell type or tissue
0.76
histone modification site profile
0.67
phenotype
0.63
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
KPTN
Tbio
Novelty:  0.06841936
p_int:  1
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
C12orf66
Tbio
Novelty:  1.38775963
p_int:  0.999999963
p_ni:  3.7e-8
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty:  0.06995258
p_int:  0.999999629
p_ni:  3.71e-7
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
SH3PXD2B
Tbio
Novelty:  0.04207866
p_int:  0.999998504
p_ni:  0.000001496
Score:  0.204
Data Source:  BioPlex,STRINGDB
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.999996635
p_ni:  0.000003365
Data Source:  BioPlex
OTUD3
Tbio
Novelty:  0.11839931
p_int:  0.999978319
p_ni:  0.000021681
Data Source:  BioPlex
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.99995292
p_ni:  0.00004708
Data Source:  BioPlex
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999949759
p_ni:  0.000050241
Score:  0.681
Data Source:  BioPlex,Reactome,STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
p_int:  0.999114421
p_ni:  0.000885579
Score:  0.234
Data Source:  BioPlex,STRINGDB
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.996593523
p_ni:  0.003406477
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
2
7
96.1
sex hormone-binding globulin measurement
4
1
4
76.1
estradiol measurement
1
1
1
70
mean corpuscular volume
1
1
1
68.8
vital capacity
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
96.1
sex hormone-binding globulin measurement
4
76.1
estradiol measurement
1
70
mean corpuscular volume
1
68.8
vital capacity
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin alpha FG-GAP repeat containing 2
VGNC:52049
451749
Mouse
MGI:1915450
101142
Rat
RGD:1311944
362441
Dog
integrin alpha FG-GAP repeat containing 2
VGNC:42119
611853
Horse
integrin alpha FG-GAP repeat containing 2
VGNC:19159
100050697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin alpha FG-GAP repeat containing 2
Mouse
Rat
Dog
integrin alpha FG-GAP repeat containing 2
Horse
integrin alpha FG-GAP repeat containing 2
Publication Statistics
PubMed Score 2.55
PubMed score by year
PubTator Score 1.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title