Tdark ISY1 Pre-mRNA-splicing factor ISY1 homolog

Protein Summary

Description

May play a role in pre-mRNA splicing as component of the spliceosome. This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9ULR0
• Q96IL2
• Q9BT05

Gene Name

• ISY1

Ensembl ID

• ENST00000273541
• ENSP00000273541
• ENSG00000240682
• ENST00000393295
• ENSP00000376973

Symbol

• KIAA1160
• ISY1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor perturbation	0.84
transcription factor binding site profile	0.75
transcription factor	0.64
cell type or tissue	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.1   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 37   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.1   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0