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Tdark
ISY1
Pre-mRNA-splicing factor ISY1 homolog

Protein Summary
Description
May play a role in pre-mRNA splicing as component of the spliceosome. This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273541
  • ENSP00000273541
  • ENSG00000240682
  • ENST00000393295
  • ENSP00000376973

Symbol
  • KIAA1160
  • ISY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.75
transcription factor
0.64
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.99999913
p_ni:  8.7e-7
Score:  0.862
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999949995
p_ni:  0.000050004
Score:  0.898
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999860789
p_ni:  0.000139211
Data Source:  BioPlex
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999045744
p_ni:  0.000953539
p_wrong:  7.18e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.998658326
p_ni:  0.001340952
p_wrong:  7.22e-7
Score:  0.939
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.9972833
p_ni:  0.002715946
p_wrong:  7.54e-7
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.996521082
p_ni:  0.003428337
p_wrong:  0.000050581
Data Source:  BioPlex
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.99177265
p_ni:  0.008227347
p_wrong:  3e-9
Score:  0.82
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.991765832
p_ni:  0.008091343
p_wrong:  0.000142826
Data Source:  BioPlex
YJU2
Tdark
Novelty:  0.75647391
p_int:  0.990361269
p_ni:  0.009638726
p_wrong:  5e-9
Score:  0.777
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
DNA Repair (R-HSA-73894)

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Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Metabolism of RNA
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
84.1
platelet count
1
1
1
81.5
platelet crit
1
1
1
59.6
BMI-adjusted hip circumference
1
1
1
47.7
hip circumference
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
84.1
platelet count
1
81.5
platelet crit
1
59.6
BMI-adjusted hip circumference
1
47.7
hip circumference
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB43, member RAS oncogene family
705873
Mouse
MGI:1923310
57905
Dog
ISY1 splicing factor homolog
484629
Cow
ISY1 splicing factor homolog (S. cerevisiae)
783414
Platypus
pre-mRNA-splicing factor ISY1 homolog
100073658
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB43, member RAS oncogene family
Mouse
Dog
ISY1 splicing factor homolog
Cow
ISY1 splicing factor homolog (S. cerevisiae)
Platypus
pre-mRNA-splicing factor ISY1 homolog
Publication Statistics
PubMed Score 0.07
PubMed score by year
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Related Publications
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PMID
Year
Title