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Tbio
IST1
IST1 homolog

Protein Summary
Description
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329908
  • ENSP00000330408
  • ENSG00000182149
  • ENST00000378798
  • ENSP00000368075
  • ENST00000378799
  • ENSP00000368076
  • ENST00000535424
  • ENSP00000438399
  • ENST00000538850
  • ENSP00000463711
  • ENST00000541571
  • ENSP00000455860
  • ENST00000544564
  • ENSP00000457844
  • ENST00000606369
  • ENSP00000475853

Symbol
  • KIAA0174
  • OLC1
  • CHMP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
disease perturbation
0.97
virus perturbation
0.92
co-expressed gene
0.89
kinase perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
LSMEM2
Tdark
Novelty:  43
p_int:  0.999999603
p_ni:  3.68e-7
p_wrong:  2.9e-8
Data Source:  BioPlex
SPAST
Tbio
Novelty:  0.00303236
p_int:  0.999999034
p_ni:  7.74e-7
p_wrong:  1.92e-7
Score:  0.803
Data Source:  BioPlex,STRINGDB
CHMP1A
Tbio
Novelty:  0.03969333
p_int:  0.998374576
p_ni:  0.001625314
p_wrong:  1.11e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.962583309
p_ni:  0.001030895
p_wrong:  0.036385796
Score:  0.166
Data Source:  BioPlex,STRINGDB
HEY2
Tbio
Family:  TF
Novelty:  0.00569776
p_int:  0.915958092
p_ni:  0.000173996
p_wrong:  0.083867912
Score:  0.855
Data Source:  BioPlex,STRINGDB
CHMP1B
Tbio
Novelty:  0.06982523
Score:  0.997
Data Source:  STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.989
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.989
Data Source:  STRINGDB
CHMP5
Tbio
Novelty:  0.03378716
Score:  0.972
Data Source:  STRINGDB
ULK3
Tchem
Family:  Kinase
Novelty:  0.0783598
Score:  0.971
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
5
11
13
97.2
low density lipoprotein cholesterol measurement
5
10
12
97.1
apolipoprotein B measurement
2
9
9
94.4
reticulocyte count
2
1
2
71.2
intelligence
3
5
2
6
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
13
97.2
low density lipoprotein cholesterol measurement
12
97.1
apolipoprotein B measurement
9
94.4
reticulocyte count
2
71.2
intelligence
2
6
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919205
71955
Rat
RGD:1307799
307833
Dog
IST1, ESCRT-III associated factor
VGNC:49862
479667
Horse
IST1, ESCRT-III associated factor
VGNC:51202
100146422
Cow
IST1, ESCRT-III associated factor
VGNC:30304
508900
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
IST1, ESCRT-III associated factor
Horse
IST1, ESCRT-III associated factor
Cow
IST1, ESCRT-III associated factor
Publication Statistics
PubMed Score 53.42
PubMed score by year
PubTator Score 23.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title