Protein Summary
ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this g ...more
- ENST00000329908
- ENSP00000330408
- ENSG00000182149
- ENST00000378798
- ENSP00000368075
- ENST00000378799
- ENSP00000368076
- ENST00000535424
- ENSP00000438399
- ENST00000538850
- ENSP00000463711
- ENST00000541571
- ENSP00000455860
- ENST00000544564
- ENSP00000457844
- ENST00000606369
- ENSP00000475853
- KIAA0174
- OLC1
- CHMP8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.98 | ||
disease perturbation | 0.97 | ||
virus perturbation | 0.92 | ||
co-expressed gene | 0.89 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.42 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 106 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.42 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 106 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (159)
SPAST
Novelty: 0.00303236
p_int: 0.999999034
p_ni: 7.74e-7
p_wrong: 1.92e-7
Score: 0.803
Data Source: BioPlex,STRINGDB
CHMP1A
Novelty: 0.03969333
p_int: 0.998374576
p_ni: 0.001625314
p_wrong: 1.11e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
USP47
Family: Enzyme
Novelty: 0.07579226
p_int: 0.962583309
p_ni: 0.001030895
p_wrong: 0.036385796
Score: 0.166
Data Source: BioPlex,STRINGDB
HEY2
Family: TF
Novelty: 0.00569776
p_int: 0.915958092
p_ni: 0.000173996
p_wrong: 0.083867912
Score: 0.855
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (5)
Components (10)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
total cholesterol measurement | 5 | 11 | 13 | 97.2 | |||||
low density lipoprotein cholesterol measurement | 5 | 10 | 12 | 97.1 | |||||
apolipoprotein B measurement | 2 | 9 | 9 | 94.4 | |||||
reticulocyte count | 2 | 1 | 2 | 71.2 | |||||
intelligence | 3 | 5 | 2 | 6 | 70.2 | ||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
total cholesterol measurement | 13 | 97.2 | |||||
low density lipoprotein cholesterol measurement | 12 | 97.1 | |||||
apolipoprotein B measurement | 9 | 94.4 | |||||
reticulocyte count | 2 | 71.2 | |||||
intelligence | 2 | 6 | 70.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1919205 | 71955 | ||||||
Rat | RGD:1307799 | 307833 | ||||||
Dog | IST1, ESCRT-III associated factor | VGNC:49862 | 479667 | |||||
Horse | IST1, ESCRT-III associated factor | VGNC:51202 | 100146422 | |||||
Cow | IST1, ESCRT-III associated factor | VGNC:30304 | 508900 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | IST1, ESCRT-III associated factor | |||||
Horse | IST1, ESCRT-III associated factor | |||||
Cow | IST1, ESCRT-III associated factor | |||||
Publication Statistics
PubMed Score 53.42
PubMed score by year
PubTator Score 23.43
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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