Tbio IST1 IST1 homolog

Protein Summary

Description

ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P53990
• A8KAH5
• J3QLU7
• Q3SYM4
• Q9BQ81
• Q9BWN2
• hIST1

Gene Name

• IST1

Ensembl ID

• ENST00000329908
• ENSP00000330408
• ENSG00000182149
• ENST00000378798
• ENSP00000368075
• ENST00000378799
• ENSP00000368076
• ENST00000535424
• ENSP00000438399
• ENST00000538850
• ENSP00000463711
• ENST00000541571
• ENSP00000455860
• ENST00000544564
• ENSP00000457844
• ENST00000606369
• ENSP00000475853

Symbol

• KIAA0174
• OLC1
• CHMP8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
disease perturbation	0.97
virus perturbation	0.92
co-expressed gene	0.89
kinase perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.42   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (159)

Explore Interacting Targets

1 – 10 of 159

• See Interactions on String-DB

LSMEM2

Tdark

Novelty:  43

p_int:  0.999999603

p_ni:  3.68e-7

p_wrong:  2.9e-8

Data Source:  BioPlex

SPAST

Tbio

Novelty:  0.00303236

p_int:  0.999999034

p_ni:  7.74e-7

p_wrong:  1.92e-7

Score:  0.803

Data Source:  BioPlex,STRINGDB

CHMP1A

Tbio

Novelty:  0.03969333

p_int:  0.998374576

p_ni:  0.001625314

p_wrong:  1.11e-7

Score:  0.995

Data Source:  BioPlex,STRINGDB

USP47

Tchem

Family:  Enzyme

Novelty:  0.07579226

p_int:  0.962583309

p_ni:  0.001030895

p_wrong:  0.036385796

Score:  0.166

Data Source:  BioPlex,STRINGDB

HEY2

Tbio

Family:  TF

Novelty:  0.00569776

p_int:  0.915958092

p_ni:  0.000173996

p_wrong:  0.083867912

Score:  0.855

Data Source:  BioPlex,STRINGDB

CHMP1B

Tbio

Novelty:  0.06982523

Score:  0.997

Data Source:  STRINGDB

VPS4B

Tchem

Novelty:  0.00788708

Score:  0.989

Data Source:  STRINGDB

VTA1

Tbio

Novelty:  0.01697854

Score:  0.989

Data Source:  STRINGDB

CHMP5

Tbio

Novelty:  0.03378716

Score:  0.972

Data Source:  STRINGDB

ULK3

Tchem

Family:  Kinase

Novelty:  0.0783598

Score:  0.971

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (5)

Components (10)

Processes (13)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
MIT domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein domain specific binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (21)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	5	11	13		97.2
low density lipoprotein cholesterol measurement	EFO_0004611	5	10	12		97.1
apolipoprotein B measurement	EFO_0004615	2	9	9		94.4
reticulocyte count	EFO_0007986	2	1	2		71.2
intelligence	EFO_0004337	3	5	2	6	70.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
total cholesterol measurement	EFO_0004574	13		97.2
low density lipoprotein cholesterol measurement	EFO_0004611	12		97.1
apolipoprotein B measurement	EFO_0004615	9		94.4
reticulocyte count	EFO_0007986	2		71.2
intelligence	EFO_0004337	2	6	70.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
alcohol use disorder measurement
apolipoprotein B measurement
cigarettes per day measurement
cognitive function measurement
fibrinogen measurement
grip strength measurement
high density lipoprotein cholesterol measurement
intelligence
LDL cholesterol change measurement

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	increased sodium tolerance 1 homolog (yeast)	MGI:1919205	71955
Rat	IST1, ESCRT-III associated factor	RGD:1307799	307833
Dog	IST1, ESCRT-III associated factor	VGNC:49862	479667
Horse	IST1, ESCRT-III associated factor	VGNC:51202	100146422
Cow	IST1, ESCRT-III associated factor	VGNC:30304	508900

Species	Name	OMA	EggNOG	Inparanoid
Mouse	increased sodium tolerance 1 homolog (yeast)
Rat	IST1, ESCRT-III associated factor
Dog	IST1, ESCRT-III associated factor
Horse	IST1, ESCRT-III associated factor
Cow	IST1, ESCRT-III associated factor

Publication Statistics

PubMed Score 53.42

PubMed score by year

Reset Zoom

PubTator Score 23.43

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (48)

GeneRif Annotations (18)

Items per page:

10

0 of 0

PMID	Year	Title