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Tbio
ISOC2
Isochorismatase domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000085068
  • ENSP00000085068
  • ENSG00000063241
  • ENST00000425675
  • ENSP00000401726
  • ENST00000438389
  • ENSP00000406364
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cell type or tissue
0.71
transcription factor binding site profile
0.64
transcription factor
0.53
cellular component
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.67   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.67   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
ALAD
Tbio
Family:  Enzyme
Novelty:  0.00092757
p_int:  0.999978163
p_ni:  0.00002183
p_wrong:  8e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.999511666
p_ni:  0.000382261
p_wrong:  0.000106073
Score:  0.249
Data Source:  BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.99793729
p_ni:  0.002062696
p_wrong:  1.4e-8
Score:  0.535
Data Source:  BioPlex,STRINGDB
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.997819309
p_ni:  0.001604872
p_wrong:  0.000575819
Score:  0.245
Data Source:  BioPlex,STRINGDB
DNLZ
Tdark
Novelty:  0.10113346
p_int:  0.995151512
p_ni:  0.004847814
p_wrong:  6.74e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
p_int:  0.988474824
p_ni:  0.007386804
p_wrong:  0.004138373
Data Source:  BioPlex
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.979434238
p_ni:  0.020565762
Score:  0.178
Data Source:  BioPlex,STRINGDB
IL12RB1
Tbio
Novelty:  0.00398741
p_int:  0.977903122
p_ni:  0.015548749
p_wrong:  0.00654813
Score:  0.237
Data Source:  BioPlex,STRINGDB
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.97458676
p_ni:  0.025413087
p_wrong:  1.53e-7
Score:  0.527
Data Source:  BioPlex,STRINGDB
MPP2
Tbio
Novelty:  0.0372293
p_int:  0.966552083
p_ni:  0.033447771
p_wrong:  1.45e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
2
6
92.5
2
1
0
1.3
73.5
birth weight
1
1
1
43.1
BMI-adjusted waist-hip ratio
3
1
3
38.6
smoking status measurement
2
1
2
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
6
92.5
0
1.3
73.5
birth weight
1
43.1
BMI-adjusted waist-hip ratio
3
38.6
smoking status measurement
2
38.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isochorismatase domain containing 2
VGNC:11137
736238
Macaque
isochorismatase domain containing 2
700714
Mouse
MGI:3609243
664994
Rat
RGD:1592677
684270
Dog
isochorismatase domain containing 2
VGNC:42113
609103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isochorismatase domain containing 2
Macaque
isochorismatase domain containing 2
Mouse
Rat
Dog
isochorismatase domain containing 2
Publication Statistics
PubMed Score 2.67
PubMed score by year
PubTator Score 1.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title