Tbio ISG20 Interferon-stimulated gene 20 kDa protein

Protein Summary

Description

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Uniprot Accession IDs

• Q96AZ6
• O00441
• O00586

Gene Name

• ISG20

Ensembl ID

• ENST00000306072
• ENSP00000306565
• ENSG00000172183
• ENST00000560741
• ENSP00000453638

Symbol

• HEM45
• CD25
• HEM45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
virus perturbation	1
gene perturbation	0.95
molecular function	0.95
transcription factor binding site profile	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 346   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0