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Tbio
ISG20
Interferon-stimulated gene 20 kDa protein

Protein Summary
Description
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306072
  • ENSP00000306565
  • ENSG00000172183
  • ENST00000560741
  • ENSP00000453638

Symbol
  • HEM45
  • CD25
  • HEM45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
gene perturbation
0.95
molecular function
0.95
transcription factor binding site profile
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.77   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
EEPD1
Tbio
Family:  Enzyme
Novelty:  0.28148309
p_int:  0.987025189
p_ni:  0.012874183
p_wrong:  0.000100628
Score:  0.25
Data Source:  BioPlex,STRINGDB
PTPRG
Tchem
Family:  Enzyme
Novelty:  0.01920574
p_int:  0.977274745
p_ni:  0.022725255
Data Source:  BioPlex
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.977176911
p_ni:  0.022823082
p_wrong:  7e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
EFR3A
Tbio
Novelty:  0.17687362
p_int:  0.957987836
p_ni:  0.042011754
p_wrong:  4.1e-7
Score:  0.195
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.902092573
p_ni:  0.055810622
p_wrong:  0.042096804
Score:  0.185
Data Source:  BioPlex,STRINGDB
GNAZ
Tbio
Novelty:  0.02008523
p_int:  0.891041007
p_ni:  0.108842399
p_wrong:  0.000116594
Data Source:  BioPlex
CSNK1G3
Tchem
Family:  Kinase
Novelty:  0.07584067
p_int:  0.887074879
p_ni:  0.112925094
p_wrong:  2.7e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.869924229
p_ni:  0.006123739
p_wrong:  0.123952032
Score:  0.157
Data Source:  BioPlex,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.858438812
p_ni:  0.141561188
Score:  0.235
Data Source:  BioPlex,STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.857453261
p_ni:  0.142517707
p_wrong:  0.000029032
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
5
8
96.4
body fat distribution
3
2
12
95.8
body height
4
3
4
95.5
BMI-adjusted hip circumference
3
6
7
89.2
BMI-adjusted waist circumference
3
1
3
70.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
8
96.4
body fat distribution
12
95.8
body height
4
95.5
BMI-adjusted hip circumference
7
89.2
BMI-adjusted waist circumference
3
70.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
interferon stimulated exonuclease gene 20
698376
Mouse
MGI:1928895
57444
Rat
RGD:1306407
293052
Dog
interferon stimulated exonuclease gene 20
VGNC:42107
488729
Horse
interferon stimulated exonuclease gene 20
VGNC:19149
100053929
Species
Name
OMA
EggNOG
Inparanoid
Macaque
interferon stimulated exonuclease gene 20
Mouse
Rat
Dog
interferon stimulated exonuclease gene 20
Horse
interferon stimulated exonuclease gene 20
Publication Statistics
PubMed Score 60.77
PubMed score by year
PubTator Score 199.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title