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Tbio
ISCU
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial

Protein Summary
Description
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311893
  • ENSP00000310623
  • ENSG00000136003
  • ENST00000392807
  • ENSP00000376554

Symbol
  • NIFUN
  • HML
  • ISU2
  • NIFU
  • NIFUN
  • hnifU
  • 2310020H20Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.94
transcription factor binding site profile
0.86
cell type or tissue
0.68
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.06   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 234   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.06   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (164)
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.996903049
p_ni:  0.000003642
p_wrong:  0.00309331
Score:  0.232
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.900651456
p_ni:  0.00079968
p_wrong:  0.098548864
Data Source:  BioPlex
LONRF1
Tdark
Family:  Enzyme
Novelty:  0.55361076
p_int:  0.778474948
p_ni:  0.000014269
p_wrong:  0.221510782
Score:  0.544
Data Source:  BioPlex,STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
Score:  0.999
Data Source:  Reactome,STRINGDB
HSCB
Tbio
Novelty:  0.01330125
Score:  0.998
Data Source:  STRINGDB
FXN
Tbio
Novelty:  0.00084064
Score:  0.997
Data Source:  Reactome,STRINGDB
SCLY
Tbio
Family:  Enzyme
Novelty:  0.05154464
Score:  0.966
Data Source:  STRINGDB
NFU1
Tbio
Novelty:  0.01465025
Score:  0.957
Data Source:  STRINGDB
FDX1
Tbio
Novelty:  0.00124491
Score:  0.956
Data Source:  STRINGDB
LYRM4
Tbio
Novelty:  0.03319832
Score:  0.952
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
4
64.2
heel bone mineral density
2
1
2
44.2
reticulocyte count
2
1
2
11.9
reticulocyte measurement
1
1
1
8.2
optic disc size measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
64.2
heel bone mineral density
2
44.2
reticulocyte count
2
11.9
reticulocyte measurement
1
8.2
optic disc size measurement
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iron-sulfur cluster assembly enzyme
452209
Macaque
iron-sulfur cluster assembly enzyme
705669
Mouse
MGI:1913633
66383
Rat
RGD:1309562
288740
Dog
iron-sulfur cluster assembly enzyme
VGNC:42105
477527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iron-sulfur cluster assembly enzyme
Macaque
iron-sulfur cluster assembly enzyme
Mouse
Rat
Dog
iron-sulfur cluster assembly enzyme
Publication Statistics
PubMed Score 245.06
PubMed score by year
PubTator Score 73.66
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title