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Tbio
ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

Protein Summary
Description
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554924
  • ENSP00000450523
  • ENSG00000165898
  • ENST00000556816
  • ENSP00000452007

Symbol
  • HBLD1
  • ISA2
  • HBLD1
  • MMDS4
  • c14_5557
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.84
histone modification site profile
0.78
kinase perturbation
0.66
cell type or tissue
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.45   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
NARF
Tbio
Novelty:  0.06990726
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.386
Data Source:  BioPlex,STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
p_int:  0.999999745
p_ni:  2.55e-7
Score:  0.959
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.999999699
p_ni:  3.01e-7
Score:  0.942
Data Source:  BioPlex,Reactome,STRINGDB
PLEKHG4
Tbio
Novelty:  0.01065982
p_int:  0.999997996
p_ni:  0.000002004
Data Source:  BioPlex
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
p_int:  0.999988204
p_ni:  0.000011795
p_wrong:  1e-9
Data Source:  BioPlex
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999975857
p_ni:  0.000024143
Data Source:  BioPlex
STRN
Tbio
Novelty:  0.01025814
p_int:  0.999822051
p_ni:  0.000177949
Data Source:  BioPlex
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.999707573
p_ni:  0.000292428
Data Source:  BioPlex
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.999670362
p_ni:  0.000329638
Data Source:  BioPlex
RAB11FIP5
Tbio
Novelty:  0.0264203
p_int:  0.999129311
p_ni:  0.000870689
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
4
5
89.4
self reported educational attainment
1
1
1
64.4
intraocular pressure measurement
3
3
3
63.6
mathematical ability
2
2
2
60.1
BMI-adjusted waist circumference
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
89.4
self reported educational attainment
1
64.4
intraocular pressure measurement
3
63.6
mathematical ability
2
60.1
BMI-adjusted waist circumference
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iron-sulfur cluster assembly 2
VGNC:12842
740854
Macaque
iron-sulfur cluster assembly 2
700004
Mouse
MGI:1921566
74316
Rat
RGD:1563216
500694
Dog
iron-sulfur cluster assembly 2
VGNC:42104
490783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iron-sulfur cluster assembly 2
Macaque
iron-sulfur cluster assembly 2
Mouse
Rat
Dog
iron-sulfur cluster assembly 2
Publication Statistics
PubMed Score 44.45
PubMed score by year
PubTator Score 12.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title