Tbio ISCA1 Iron-sulfur cluster assembly 1 homolog, mitochondrial

Protein Summary

Description

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9BUE6
• B3KP34
• B4DJI5
• Q8ND75
• Q9BZR2

Gene Name

• ISCA1

Ensembl ID

• ENST00000375991
• ENSP00000365159
• ENSG00000135070

Symbol

• HBLD2
• ISA1
• HBLD2
• MMDS5
• hIscA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
kinase perturbation	0.84
co-expressed gene	0.76
disease perturbation	0.74
transcription factor binding site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0