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Tbio
ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

Protein Summary
Description
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375991
  • ENSP00000365159
  • ENSG00000135070

Symbol
  • HBLD2
  • ISA1
  • HBLD2
  • MMDS5
  • hIscA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.84
co-expressed gene
0.76
disease perturbation
0.74
transcription factor binding site profile
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999999699
p_ni:  3.01e-7
Score:  0.942
Data Source:  BioPlex,Reactome,STRINGDB
TEPSIN
Tdark
Novelty:  0.48775142
p_int:  0.999983044
p_ni:  0.000016939
p_wrong:  1.7e-8
Data Source:  BioPlex
WDR18
Tbio
Novelty:  0.03015818
p_int:  0.999934426
p_ni:  0.00006557
p_wrong:  4e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
NUDT6
Tbio
Novelty:  0.03648851
p_int:  0.999720862
p_ni:  0.000277873
p_wrong:  0.000001266
Data Source:  BioPlex
IL1F10
Tbio
Novelty:  0.01868526
p_int:  0.999628924
p_ni:  0.000371075
p_wrong:  1e-9
Data Source:  BioPlex
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.999542124
p_ni:  0.000455484
p_wrong:  0.000002392
Data Source:  BioPlex
LRRC36
Tdark
Novelty:  2.03789632
p_int:  0.999417471
p_ni:  0.000582529
Score:  0.177
Data Source:  BioPlex,STRINGDB
TRIB1
Tbio
Family:  Kinase
Novelty:  0.01587891
p_int:  0.998761955
p_ni:  0.001238036
p_wrong:  9e-9
Score:  0.336
Data Source:  BioPlex,STRINGDB
RAB40A
Tbio
Novelty:  0.12112671
p_int:  0.997798327
p_ni:  0.002201481
p_wrong:  1.92e-7
Score:  0.619
Data Source:  BioPlex,STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
p_int:  0.997496855
p_ni:  0.002503144
p_wrong:  1e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
79
brain measurement
1
1
0
9.2
63.2
sex hormone-binding globulin measurement
4
1
4
59.5
mathematical ability
2
1
2
46.5
cortical thickness
1
1
0
6.2
27.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
79
brain measurement
0
9.2
63.2
sex hormone-binding globulin measurement
4
59.5
mathematical ability
2
46.5
cortical thickness
0
6.2
27.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
iron-sulfur cluster assembly 1
693526
Mouse
MGI:1916296
69046
Mouse
MGI:3574096
432732
Rat
RGD:727792
290985
Dog
iron-sulfur cluster assembly 1 [Source:HGNC Symbol;Acc:HGNC:28660]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
iron-sulfur cluster assembly 1
Mouse
Mouse
Rat
Dog
iron-sulfur cluster assembly 1 [Source:HGNC Symbol;Acc:HGNC:28660]
Publication Statistics
PubMed Score 88.32
PubMed score by year
PubTator Score 19.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text