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Tbio
IRGC
Interferon-inducible GTPase 5

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244314
  • ENSP00000244314
  • ENSG00000124449

Symbol
  • IIGP5
  • IRGC1
  • IFGGE
  • IRGC1
  • Iigp5
  • CINEMA
  • R30953_1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
gene perturbation
0.76
cell line
0.48
metabolite
0.45
disease perturbation
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
METTL7B
Tbio
Family:  Enzyme
Novelty:  0.0873748
p_int:  0.999981318
p_ni:  0.000018561
p_wrong:  1.22e-7
Score:  0.243
Data Source:  BioPlex,STRINGDB
RPS6KA1
Tchem
Family:  Kinase
Novelty:  0.00178073
p_int:  0.999912714
p_ni:  0.000087056
p_wrong:  2.3e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
p_int:  0.999727821
p_ni:  0.000272173
p_wrong:  6e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999255615
p_ni:  0.00069217
p_wrong:  0.000052214
Score:  0.177
Data Source:  BioPlex,STRINGDB
MYF6
Tbio
Family:  TF
Novelty:  0.00509046
p_int:  0.996994194
p_ni:  0.003005801
p_wrong:  5e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.941455411
p_ni:  0.052174986
p_wrong:  0.006369604
Data Source:  BioPlex
SLC26A6
Tbio
Family:  IC
Novelty:  0.00922143
p_int:  0.938579096
p_ni:  0.061407422
p_wrong:  0.000013482
Data Source:  BioPlex
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.933390379
p_ni:  0.06660703
p_wrong:  0.00000259
Data Source:  BioPlex
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.906947162
p_ni:  0.093052838
Data Source:  BioPlex
MCU
Tbio
Family:  IC
Novelty:  0.00114914
p_int:  0.903577259
p_ni:  0.096422741
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
4
96.9
leukocyte count
2
2
3
95.4
neutrophil percentage of leukocytes
2
2
3
93.5
urokinase plasminogen activator surface receptor measurement
1
3
3
92.4
apolipoprotein B measurement
1
2
2
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
96.9
leukocyte count
3
95.4
neutrophil percentage of leukocytes
3
93.5
urokinase plasminogen activator surface receptor measurement
3
92.4
apolipoprotein B measurement
2
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunity related GTPase cinema
VGNC:10249
468906
Mouse
MGI:2685948
210145
Rat
RGD:1311107
308428
Horse
immunity related GTPase cinema
VGNC:19140
100070279
Cow
immunity related GTPase cinema
VGNC:30281
539080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunity related GTPase cinema
Mouse
Rat
Horse
immunity related GTPase cinema
Cow
immunity related GTPase cinema
Publication Statistics
PubMed Score 8.84
PubMed score by year
PubTator Score 17.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title