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Tbio
IRF8
Interferon regulatory factor 8

Protein Summary
Description
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed:29434592). Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268638
  • ENSP00000268638
  • ENSG00000140968

Symbol
  • ICSBP1
  • ICSBP
  • IRF-8
  • ICSBP1
  • IMD32A
  • IMD32B
  • H-ICSBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
kinase perturbation
0.93
gene perturbation
0.86
protein domain
0.85
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.15   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 425   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 382.15   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 425   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (395)
TRIM21
Tbio
Family:  Enzyme
Novelty:  0.00069504
Score:  0.965
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.963
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.958
Data Source:  STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.955
Data Source:  STRINGDB
P20039
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
Q95IE3
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
Q9GIY3
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
P04229
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
P13761
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
P01912
Tbio
Novelty:  0.00240724
Score:  0.952
Data Source:  STRINGDB
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
19
19
99.9
monocyte percentage of leukocytes
2
24
27
99.9
granulocyte percentage of myeloid white cells
1
10
10
99.6
neutrophil percentage of leukocytes
2
7
7
98.5
neutrophil count
3
6
6
97.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
19
99.9
monocyte percentage of leukocytes
27
99.9
granulocyte percentage of myeloid white cells
10
99.6
neutrophil percentage of leukocytes
7
98.5
neutrophil count
6
97.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 8
VGNC:5813
454294
Macaque
interferon regulatory factor 8
693933
Mouse
MGI:96395
15900
Rat
RGD:1312024
292060
Dog
interferon regulatory factor 8
VGNC:42096
489673
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 8
Macaque
interferon regulatory factor 8
Mouse
Rat
Dog
interferon regulatory factor 8
Publication Statistics
PubMed Score 382.15
PubMed score by year
PubTator Score 169.73
PubTator score by year
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Related Publications
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PMID
Year
Title