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Tbio
IRF3
Interferon regulatory factor 3

Protein Summary
Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309877
  • ENSP00000310127
  • ENSG00000126456
  • ENST00000377139
  • ENSP00000366344
  • ENST00000442265
  • ENSP00000400378
  • ENST00000596765
  • ENSP00000470512
  • ENST00000597198
  • ENSP00000469113
  • ENST00000599223
  • ENSP00000471358
  • ENST00000600022
  • ENSP00000472700
  • ENST00000601291
  • ENSP00000471896

Symbol
  • IIAE7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.96
hub protein
0.96
kinase
0.87
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.58   (req: < 5)
Gene RIFs: 240   (req: <= 3)
Antibodies: 1189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1214.58   (req: >= 5)
Gene RIFs: 240   (req: > 3)
Antibodies: 1189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0