Tbio IRF2BP1 Interferon regulatory factor 2-binding protein 1

Protein Summary

Description

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

Uniprot Accession IDs

• Q8IU81
• Q53EL7
• Q6DC95
• Q9BRZ9
• Q9Y4P4
• IRF-2-binding protein 1

Gene Name

• IRF2BP1

Ensembl ID

• ENST00000302165
• ENSP00000307265
• ENSG00000170604

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
disease perturbation	0.9
cell type or tissue	0.81
transcription factor binding site profile	0.76
small molecule perturbation	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0