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Tchem
IRAK4
Interleukin-1 receptor-associated kinase 4

Protein Summary
Description
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431837
  • ENSP00000390327
  • ENSG00000198001
  • ENST00000440781
  • ENSP00000408734
  • ENST00000551736
  • ENSP00000446490
  • ENST00000613694
  • ENSP00000479889

Symbol
  • IPD1
  • REN64
  • IRAK-4
  • NY-REN-64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.87
virus perturbation
0.83
kinase perturbation
0.76
small molecule perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.33   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 712   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.33   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 712   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1052
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0