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Tchem
IRAK3
Interleukin-1 receptor-associated kinase 3

Protein Summary
Description
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261233
  • ENSP00000261233
  • ENSG00000090376
  • ENST00000457197
  • ENSP00000409852

Symbol
  • ASRT5
  • IRAKM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.97
PubMedID
0.84
tissue sample
0.7
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.49   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 518   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.49   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (82)
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999984325
p_ni:  0.000015562
p_wrong:  1.12e-7
Score:  0.263
Data Source:  BioPlex,STRINGDB
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.999927193
p_ni:  0.000072807
Data Source:  BioPlex
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.999885915
p_ni:  0.00002936
p_wrong:  0.000084726
Data Source:  BioPlex
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
p_int:  0.991671418
p_ni:  0.008328582
Score:  0.361
Data Source:  BioPlex,STRINGDB
AZI2
Tbio
Novelty:  0.23255317
p_int:  0.987415372
p_ni:  0.000576863
p_wrong:  0.012007764
Score:  0.189
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.949113402
p_ni:  0.050886598
Score:  0.192
Data Source:  BioPlex,STRINGDB
MYD88
Tbio
Novelty:  0.00037931
Score:  0.995
Data Source:  STRINGDB
IRAK4
Tchem
Family:  Kinase
Novelty:  0.00344058
Score:  0.989
Data Source:  STRINGDB
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.985
Data Source:  STRINGDB
IRAK2
Tbio
Family:  Kinase
Novelty:  0.01496024
Score:  0.985
Data Source:  STRINGDB
Pathways (110)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-1 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-1 family signaling
Interleukin-1 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
4
5
87.8
age at menopause
1
1
1
80.4
BMI-adjusted hip circumference
1
2
2
57.6
basophil percentage of leukocytes
1
1
1
53.3
hip circumference
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
87.8
age at menopause
1
80.4
BMI-adjusted hip circumference
2
57.6
basophil percentage of leukocytes
1
53.3
hip circumference
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor associated kinase 3
VGNC:5433
467058
Macaque
interleukin 1 receptor associated kinase 3
717845
Mouse
MGI:1921164
73914
Rat
RGD:1308846
314870
Dog
interleukin 1 receptor associated kinase 3
VGNC:54151
481150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor associated kinase 3
Macaque
interleukin 1 receptor associated kinase 3
Mouse
Rat
Dog
interleukin 1 receptor associated kinase 3
Publication Statistics
PubMed Score 126.49
PubMed score by year
PubTator Score 63.29
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title