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Tbio
IQSEC2
IQ motif and SEC7 domain-containing protein 2

Protein Summary
Description
Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375365
  • ENSP00000364514
  • ENSG00000124313
  • ENST00000396435
  • ENSP00000379712
  • ENST00000639161
  • ENSP00000491796
  • ENST00000642864
  • ENSP00000495726

Symbol
  • KIAA0522
  • MRX1
  • BRAG1
  • MRX18
  • MRX78
  • IQ-ArfGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.76
protein domain
0.73
small molecule perturbation
0.62
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0