IQSEC2
IQ motif and SEC7 domain-containing protein 2
Protein Summary
Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins. This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
- ENST00000375365
- ENSP00000364514
- ENSG00000124313
- ENST00000396435
- ENSP00000379712
- ENST00000639161
- ENSP00000491796
- ENST00000642864
- ENSP00000495726
- KIAA0522
- MRX1
- BRAG1
- MRX18
- MRX78
- IQ-ArfGEF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.78 | ||
cell type or tissue | 0.76 | ||
protein domain | 0.73 | ||
small molecule perturbation | 0.62 | ||
cell line | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.03 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 59 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.03 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 59 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0