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Tbio
IQGAP3
Ras GTPase-activating-like protein IQGAP3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361170
  • ENSP00000354451
  • ENSG00000183856
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
protein domain
0.85
kinase perturbation
0.81
biological process
0.75
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.77   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.77   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ANLN
Tbio
Novelty:  0.00542857
p_int:  0.999999776
p_ni:  2.23e-7
p_wrong:  1e-9
Score:  0.383
Data Source:  BioPlex,STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999832042
p_ni:  0.000167791
p_wrong:  1.67e-7
Score:  0.879
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.990214797
p_ni:  0.009785203
Data Source:  BioPlex
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.951737967
p_ni:  0.048262033
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.940160991
p_ni:  0.059839009
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.936533135
p_ni:  0.063466865
Data Source:  BioPlex
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.915810087
p_ni:  0.084189913
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.91241215
p_ni:  0.08758785
Data Source:  BioPlex
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.908239301
p_ni:  0.091760699
Score:  0.322
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
p_int:  0.844916553
p_ni:  0.155083448
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
CHRM3
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
BDKRB2
Tclin
Family:  GPCR
KEGG Distance:  4
Common Pathways:  1
SRC
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  1
Pathways (11)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate IQGAPs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate IQGAPs
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
91.8
4
4
0
1.1
90.6
platelet count
2
2
2
81.2
TPE interval measurement
1
1
3
79.6
BMI-adjusted waist circumference
2
5
5
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
91.8
0
1.1
90.6
platelet count
2
81.2
TPE interval measurement
3
79.6
BMI-adjusted waist circumference
5
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 3
VGNC:1276
457397
Macaque
IQ motif containing GTPase activating protein 3
719575
Mouse
MGI:3028642
404710
Rat
RGD:1305951
310621
Dog
IQ motif containing GTPase activating protein 3
VGNC:53495
490412
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing GTPase activating protein 3
Macaque
IQ motif containing GTPase activating protein 3
Mouse
Rat
Dog
IQ motif containing GTPase activating protein 3
Publication Statistics
PubMed Score 26.77
PubMed score by year
PubTator Score 10.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title