Tbio IQGAP1 Ras GTPase-activating-like protein IQGAP1

Protein Summary

Description

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816). This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P46940
• A7MBM3

Gene Name

• IQGAP1

Ensembl ID

• ENST00000268182
• ENSP00000268182
• ENSG00000140575

Symbol

• KIAA0051
• SAR1
• p195
• HUMORFA01

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
molecular function	0.99
protein domain	0.99
transcription factor perturbation	0.99

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Gtpase-activating-like Protein Iqgap1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Gtpase-activating-like Protein Iqgap1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.73   (req: < 5)

Gene RIFs: 194   (req: <= 3)

Antibodies: 359   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.73   (req: >= 5)

Gene RIFs: 194   (req: > 3)

Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0