Tdark IQCF1 IQ domain-containing protein F1

Protein Summary

Description

Involved in sperm capacitation and acrosome reaction.

Uniprot Accession IDs

• Q8N6M8
• Q8N711

Gene Name

• IQCF1

Ensembl ID

• ENST00000310914
• ENSP00000307958
• ENSG00000173389

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.64
cell type or tissue	0.62
tissue	0.54
gene perturbation	0.5
tissue sample	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (50)

Explore Interacting Targets

1 – 10 of 50

• See Interactions on String-DB

PACS1

Tbio

Novelty:  0.02030091

p_int:  0.999995609

p_ni:  0.000001821

p_wrong:  0.00000257

Score:  0.795

Data Source:  BioPlex,STRINGDB

ARHGAP5

Tbio

Family:  Enzyme

Novelty:  0.03683127

p_int:  0.999977033

p_ni:  0.000022967

Score:  0.189

Data Source:  BioPlex,STRINGDB

ZWILCH

Tbio

Novelty:  0.05184569

p_int:  0.99981314

p_ni:  0.000176734

p_wrong:  0.000010126

Score:  0.163

Data Source:  BioPlex,STRINGDB

WDR37

Tbio

Novelty:  0.1677975

p_int:  0.996398104

p_ni:  0.002859808

p_wrong:  0.000742088

Data Source:  BioPlex

TTF2

Tbio

Novelty:  0.20281859

p_int:  0.995546489

p_ni:  0.004453511

Data Source:  BioPlex

DIS3

Tbio

Family:  Enzyme

Novelty:  0.00961238

p_int:  0.995112405

p_ni:  0.004887595

Data Source:  BioPlex

FAM118B

Tdark

Novelty:  0.48168976

p_int:  0.992156642

p_ni:  0.007843352

p_wrong:  6e-9

Data Source:  BioPlex

PRTFDC1

Tbio

Family:  Enzyme

Novelty:  0.13607881

p_int:  0.989396918

p_ni:  0.002075391

p_wrong:  0.008527691

Data Source:  BioPlex

LRRC40

Tdark

Novelty:  2.43377466

p_int:  0.9807447

p_ni:  0.019181412

p_wrong:  0.000073888

Data Source:  BioPlex

AP3M2

Tbio

Novelty:  0.18164255

p_int:  0.974359398

p_ni:  0.0256406

p_wrong:  2e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (1)

Components (1)

Processes (2)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
calmodulin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1	1	1		69.4
macrophage inflammatory protein 1b measurement	EFO_0008219	1	1	1		33.1
urate measurement	EFO_0004531	1	1	1		12.2
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		10.6
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		8.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1		69.4
macrophage inflammatory protein 1b measurement	EFO_0008219	1		33.1
urate measurement	EFO_0004531	1		12.2
high density lipoprotein cholesterol measurement	EFO_0004612	1		10.6
apolipoprotein A 1 measurement	EFO_0004614	1		8.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasmic vesicle
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
body height
high density lipoprotein cholesterol measurement
IGF-1 measurement
low density lipoprotein cholesterol measurement
macrophage inflammatory protein 1b measurement
sporadic amyotrophic lateral sclerosis
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	IQ motif containing F1	VGNC:1850	470823
Macaque	IQ motif containing F1		699719
Mouse	IQ motif containing F1	MGI:1921517	74267
Rat	IQ motif containing F1	RGD:1565640	503227
Dog	IQ motif containing F1	VGNC:42077	476604

Species	Name	OMA	EggNOG	Inparanoid
Chimp	IQ motif containing F1
Macaque	IQ motif containing F1
Mouse	IQ motif containing F1
Rat	IQ motif containing F1
Dog	IQ motif containing F1

Publication Statistics

PubMed Score 1.22

PubMed score by year

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PubTator Score 0.50

PubTator score by year

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Related Publications

Text Mined References (5)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title