You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
IQCF1
IQ domain-containing protein F1

Protein Summary
Description
Involved in sperm capacitation and acrosome reaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310914
  • ENSP00000307958
  • ENSG00000173389
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.64
cell type or tissue
0.62
tissue
0.54
gene perturbation
0.5
tissue sample
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
PACS1
Tbio
Novelty:  0.02030091
p_int:  0.999995609
p_ni:  0.000001821
p_wrong:  0.00000257
Score:  0.795
Data Source:  BioPlex,STRINGDB
ARHGAP5
Tbio
Family:  Enzyme
Novelty:  0.03683127
p_int:  0.999977033
p_ni:  0.000022967
Score:  0.189
Data Source:  BioPlex,STRINGDB
ZWILCH
Tbio
Novelty:  0.05184569
p_int:  0.99981314
p_ni:  0.000176734
p_wrong:  0.000010126
Score:  0.163
Data Source:  BioPlex,STRINGDB
WDR37
Tbio
Novelty:  0.1677975
p_int:  0.996398104
p_ni:  0.002859808
p_wrong:  0.000742088
Data Source:  BioPlex
TTF2
Tbio
Novelty:  0.20281859
p_int:  0.995546489
p_ni:  0.004453511
Data Source:  BioPlex
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.995112405
p_ni:  0.004887595
Data Source:  BioPlex
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.992156642
p_ni:  0.007843352
p_wrong:  6e-9
Data Source:  BioPlex
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.989396918
p_ni:  0.002075391
p_wrong:  0.008527691
Data Source:  BioPlex
LRRC40
Tdark
Novelty:  2.43377466
p_int:  0.9807447
p_ni:  0.019181412
p_wrong:  0.000073888
Data Source:  BioPlex
AP3M2
Tbio
Novelty:  0.18164255
p_int:  0.974359398
p_ni:  0.0256406
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
macrophage inflammatory protein 1b measurement
1
1
1
33.1
urate measurement
1
1
1
12.2
high density lipoprotein cholesterol measurement
1
1
1
10.6
apolipoprotein A 1 measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
macrophage inflammatory protein 1b measurement
1
33.1
urate measurement
1
12.2
high density lipoprotein cholesterol measurement
1
10.6
apolipoprotein A 1 measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing F1
VGNC:1850
470823
Macaque
IQ motif containing F1
699719
Mouse
MGI:1921517
74267
Rat
RGD:1565640
503227
Dog
IQ motif containing F1
VGNC:42077
476604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing F1
Macaque
IQ motif containing F1
Mouse
Rat
Dog
IQ motif containing F1
Publication Statistics
PubMed Score 1.22
PubMed score by year
PubTator Score 0.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title