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Tdark
IQCA1
Dynein regulatory complex protein 11

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. The protein encoded by this gene is a member of the ATPases Associated with diverse cellular Activities (AAA) superfamily. Members of this superfamily, found in all organisms, participate in a large number of cellular processes and contain the ATPase module consisting of an alpha-beta-alpha core domain and the Walker A and B motifs of the P-loop NTPases. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254653
  • ENSP00000254653
  • ENSG00000132321
  • ENST00000309507
  • ENSP00000311951
  • ENST00000409907
  • ENSP00000387347

Symbol
  • DRC11
  • IQCA
  • IQCA
  • DRC11
  • 4930465P12Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
molecular function
0.73
tissue
0.62
tissue sample
0.56
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
IQCG
Tbio
Novelty:  0.19968917
Score:  0.819
Data Source:  STRINGDB
IQCD
Tbio
Novelty:  0.21789956
Score:  0.771
Data Source:  STRINGDB
UBXN7
Tbio
Novelty:  0.07437638
Score:  0.758
Data Source:  STRINGDB
EFCAB2
Tdark
Novelty:  0.26420728
Score:  0.747
Data Source:  STRINGDB
TCTE1
Tbio
Novelty:  0.11008102
Score:  0.717
Data Source:  STRINGDB
DRC7
Tdark
Novelty:  0.40606004
Score:  0.702
Data Source:  STRINGDB
ARL14
Tbio
Family:  Enzyme
Novelty:  0.06448148
Score:  0.702
Data Source:  STRINGDB
DTL
Tbio
Novelty:  0.01659105
Score:  0.688
Data Source:  STRINGDB
CCDC39
Tbio
Novelty:  0.0150835
Score:  0.666
Data Source:  STRINGDB
GAS8
Tbio
Novelty:  0.03540885
Score:  0.664
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
24.5
1
1
0
5.7
4.2
white matter microstructure measurement
1
1
1
0.8
mean fractional anisotropy measurement
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
24.5
0
5.7
4.2
white matter microstructure measurement
1
0.8
mean fractional anisotropy measurement
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing with AAA domain 1
VGNC:1980
460042
Macaque
IQ motif containing with AAA domain 1
694173
Mouse
MGI:1922168
74918
Rat
Dog
IQ motif containing with AAA domain 1
VGNC:42072
477415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IQ motif containing with AAA domain 1
Macaque
IQ motif containing with AAA domain 1
Mouse
Rat
Dog
IQ motif containing with AAA domain 1
Publication Statistics
PubMed Score 3.94
PubMed score by year
PubTator Score 2.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title