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Tbio
IPP
Actin-binding protein IPP

Protein Summary
Description
May play a role in organizing the actin cytoskeleton. The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359942
  • ENSP00000353024
  • ENSG00000197429
  • ENST00000396478
  • ENSP00000379739

Symbol
  • KLHL27
  • KLHL27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.9
virus perturbation
0.85
cell line
0.72
gene perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
KLHL28
Tdark
Novelty:  1.1777024
p_int:  0.999999933
p_ni:  5.9e-8
p_wrong:  7e-9
Score:  0.734
Data Source:  BioPlex,STRINGDB
LANCL1
Tbio
Novelty:  0.06479031
p_int:  0.999994435
p_ni:  0.000005565
Score:  0.295
Data Source:  BioPlex,STRINGDB
KLHL9
Tbio
Novelty:  0.22434722
p_int:  0.999987207
p_ni:  0.000012792
p_wrong:  1e-9
Data Source:  BioPlex
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.999909108
p_ni:  0.000090706
p_wrong:  1.85e-7
Data Source:  BioPlex
FERMT3
Tbio
Novelty:  0.01172918
p_int:  0.999292791
p_ni:  0.000698585
p_wrong:  0.000008623
Score:  0.275
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999244937
p_ni:  0.000755044
p_wrong:  2e-8
Score:  0.687
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.999176938
p_ni:  0.00082298
p_wrong:  8.2e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.999111887
p_ni:  0.000879947
p_wrong:  0.000008166
Data Source:  BioPlex
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.998437782
p_ni:  0.001534786
p_wrong:  0.000027432
Data Source:  BioPlex
ZNF517
Tdark
Family:  TF
Novelty:  1.60617003
p_int:  0.995563242
p_ni:  0.004314624
p_wrong:  0.000122134
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
80.7
erythrocyte count
2
2
2
76.6
body height
2
2
2
75.9
platelet count
3
3
3
69.9
reticulocyte count
1
1
1
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
80.7
erythrocyte count
2
76.6
body height
2
75.9
platelet count
3
69.9
reticulocyte count
1
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intracisternal A particle-promoted polypeptide
469187
Macaque
intracisternal A particle-promoted polypeptide
706893
Mouse
MGI:96581
16351
Rat
RGD:1306299
298439
Dog
intracisternal A particle-promoted polypeptide
VGNC:42070
475371
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intracisternal A particle-promoted polypeptide
Macaque
intracisternal A particle-promoted polypeptide
Mouse
Rat
Dog
intracisternal A particle-promoted polypeptide
Publication Statistics
PubMed Score 353.54
PubMed score by year
PubTator Score 25.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title