Tbio IPO9 Importin-9

Protein Summary

Description

Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity).

Uniprot Accession IDs

• Q96P70
• B1ASV5
• Q8N1Y1
• Q8N3I2
• Q8NCG9
• Q96SU6
• Q9NW01
• Q9P0A8
• Q9ULM8
• Imp9

Gene Name

• IPO9

Ensembl ID

• ENST00000361565
• ENSP00000354742
• ENSG00000198700

Symbol

• IMP9
• KIAA1192
• RANBP9
• Imp9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	0.97
kinase perturbation	0.91
transcription factor perturbation	0.88
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Transporter / Importin-9

Protein / Enzyme Modulator / G-protein / Small Gtpase / Importin-9

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Importin-9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.82   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.82   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0