Protein Summary
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this g ...more
- ENST00000256079
- ENSP00000256079
- ENSG00000133704
- ENST00000544829
- ENSP00000444520
- RANBP8
- RANBP8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.8 | ||
transcription factor perturbation | 0.8 | ||
interacting protein | 0.76 | ||
cell line | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.03 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 101.03 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (176)
ZNF331
Family: TF
Novelty: 0.05976217
p_int: 0.999809407
p_ni: 0.000190593
Score: 0.432
Data Source: BioPlex,STRINGDB
ZSCAN5A
Family: TF
Novelty: 2.15267128
p_int: 0.999542133
p_ni: 0.000457867
Score: 0.227
Data Source: BioPlex,STRINGDB
GALNT16
Family: Enzyme
Novelty: 0.34686672
p_int: 0.965270414
p_ni: 0.034729586
Score: 0.189
Data Source: BioPlex,STRINGDB
PTGER3
Family: GPCR
Novelty: 0.0012681
p_int: 0.895416335
p_ni: 0.104583665
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene Silencing by RNA | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Transcriptional regulation by small RNAs | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene Silencing by RNA | ||||
Gene expression (Transcription) | ||||
Transcriptional regulation by small RNAs | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (2)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 75.7 | |||||
monocyte count | 1 | 1 | 1 | 66.8 | |||||
birth weight | 1 | 1 | 1 | 61 | |||||
parental genotype effect measurement | 1 | 1 | 1 | 61 | |||||
waist-hip ratio | 1 | 1 | 1 | 38.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 75.7 | |||||
monocyte count | 1 | 66.8 | |||||
birth weight | 1 | 61 | |||||
parental genotype effect measurement | 1 | 61 | |||||
waist-hip ratio | 1 | 38.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | importin 8 | VGNC:5431 | 473395 | |||||
Macaque | importin 8 | 693514 | ||||||
Mouse | MGI:2444611 | 320727 | ||||||
Dog | importin 8 | VGNC:42068 | 612863 | |||||
Horse | importin 8 | VGNC:19108 | 100064845 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | importin 8 | |||||
Macaque | importin 8 | |||||
Mouse | ||||||
Dog | importin 8 | |||||
Horse | importin 8 | |||||
Publication Statistics
PubMed Score 101.03
PubMed score by year
PubTator Score 29.68
PubTator score by year
Related Publications
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Text |
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