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Tbio
IPO13
Importin-13

Protein Summary
Description
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the lo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372343
  • ENSP00000361418
  • ENSG00000117408

Symbol
  • KIAA0724
  • RANBP13
  • LGL2
  • IMP13
  • KAP13
  • RANBP13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
histone modification site profile
0.69
transcription factor
0.63
tissue
0.62
kinase perturbation
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.68   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.68   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.977423145
p_ni:  0.022576855
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.975115544
p_ni:  0.024884456
Data Source:  BioPlex
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
p_int:  0.970779854
p_ni:  0.029220145
Score:  0.18
Data Source:  BioPlex,STRINGDB
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.957692384
p_ni:  0.042307609
p_wrong:  7e-9
Data Source:  BioPlex
HIGD1A
Tbio
Novelty:  0.06248108
p_int:  0.947907303
p_ni:  0.052092697
Score:  0.193
Data Source:  BioPlex,STRINGDB
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
p_int:  0.94332796
p_ni:  0.05667204
Score:  0.189
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.943283954
p_ni:  0.056716046
Data Source:  BioPlex
B3GALT2
Tbio
Family:  Enzyme
Novelty:  0.23873109
p_int:  0.878639494
p_ni:  0.121360506
Score:  0.241
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.870158396
p_ni:  0.129841604
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.868261345
p_ni:  0.131738655
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
3
6
80.5
intelligence
4
4
2
6
76.1
cognitive function measurement
3
2
3
66.3
household income
1
2
2
60.8
age at first sexual intercourse measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
6
80.5
intelligence
2
6
76.1
cognitive function measurement
3
66.3
household income
2
60.8
age at first sexual intercourse measurement
1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
importin 13
VGNC:1274
469311
Macaque
importin 13
702007
Mouse
MGI:2385205
230673
Rat
RGD:620071
116458
Dog
importin 13
VGNC:42064
475388
Species
Name
OMA
EggNOG
Inparanoid
Chimp
importin 13
Macaque
importin 13
Mouse
Rat
Dog
importin 13
Publication Statistics
PubMed Score 54.68
PubMed score by year
PubTator Score 18.99
PubTator score by year
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Related Publications
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PMID
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