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Tbio
IP6K2
Inositol hexakisphosphate kinase 2

Protein Summary
Description
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328631
  • ENSP00000331103
  • ENSG00000068745
  • ENST00000340879
  • ENSP00000341925
  • ENST00000413298
  • ENSP00000396203
  • ENST00000416707
  • ENSP00000387759
  • ENST00000431721
  • ENSP00000414139
  • ENST00000432678
  • ENSP00000400812
  • ENST00000446860
  • ENSP00000399052

Symbol
  • IHPK2
  • PIUS
  • IHPK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
molecular function
0.96
transcription factor
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.56   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.56   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
p_int:  0.90295814
p_ni:  0.092834631
p_wrong:  0.004207229
Score:  0.337
Data Source:  BioPlex,STRINGDB
RHOU
Tbio
Family:  Enzyme
Novelty:  0.01456329
p_int:  0.84573363
p_ni:  0.000004364
p_wrong:  0.154262007
Score:  0.717
Data Source:  BioPlex,STRINGDB
PPIP5K2
Tchem
Family:  Enzyme
Novelty:  0.0284462
Score:  0.985
Data Source:  STRINGDB
PPIP5K1
Tbio
Family:  Enzyme
Novelty:  0.01175655
Score:  0.984
Data Source:  STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
Score:  0.959
Data Source:  STRINGDB
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
Score:  0.941
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.923
Data Source:  STRINGDB
MX2
Tbio
Novelty:  0.00139073
Score:  0.912
Data Source:  STRINGDB
RNASEL
Tchem
Family:  Kinase
Novelty:  0.00165549
Score:  0.911
Data Source:  STRINGDB
PSMB8
Tclin
Family:  Enzyme
Novelty:  0.00189046
Score:  0.908
Data Source:  STRINGDB
Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Inositol phosphate metabolism
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Inositol phosphate metabolism
Interferon Signaling
Interferon alpha/beta signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
5
89.5
heel bone mineral density
2
2
2
84.8
self reported educational attainment
4
5
4
5.9
84.4
waist-hip ratio
2
3
3
80.8
2
2
1
1.2
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
89.5
heel bone mineral density
2
84.8
self reported educational attainment
4
5.9
84.4
waist-hip ratio
3
80.8
1
1.2
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol hexakisphosphate kinase 2
VGNC:11418
460352
Macaque
inositol hexakisphosphate kinase 2
709221
Mouse
MGI:1923750
76500
Rat
RGD:620529
59268
Dog
inositol hexakisphosphate kinase 2
VGNC:42062
612831
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol hexakisphosphate kinase 2
Macaque
inositol hexakisphosphate kinase 2
Mouse
Rat
Dog
inositol hexakisphosphate kinase 2
Publication Statistics
PubMed Score 23.56
PubMed score by year
PubTator Score 8.81
PubTator score by year
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Related Publications
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PMID
Year
Title