Tbio IP6K1 Inositol hexakisphosphate kinase 1

Protein Summary

Description

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q92551
• A8K157
• A8MUX4
• Q7L3I7
• Q96E38
• InsP6 kinase 1

Gene Name

• IP6K1

Ensembl ID

• ENST00000321599
• ENSP00000323780
• ENSG00000176095
• ENST00000395238
• ENSP00000378659
• ENST00000460540
• ENSP00000420762
• ENST00000613416
• ENSP00000482032

Symbol

• IHPK1
• KIAA0263
• PiUS
• IHPK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
histone modification site profile	0.85
kinase perturbation	0.84
transcription factor perturbation	0.84
microRNA	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Inositol Hexakisphosphate Kinase 1

DTO Classes

Protein / Kinase / Unclassified Protein / Inositol Hexakisphosphate Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.81   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 222   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.81   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

TMEM134

Tdark

Novelty:  0.42629221

p_int:  0.99999999

p_ni:  9e-9

Data Source:  BioPlex

UBXN4

Tbio

Novelty:  0.16206743

p_int:  0.999999986

p_ni:  1.4e-8

Score:  0.679

Data Source:  BioPlex,STRINGDB

VSIG1

Tbio

Novelty:  0.15442611

p_int:  0.9999976

p_ni:  0.0000024

Data Source:  BioPlex

FGFR2

Tclin

Family:  Kinase

Novelty:  0.00066613

p_int:  0.999993228

p_ni:  0.000006772

Score:  0.23

Data Source:  BioPlex,STRINGDB

TFCP2

Tbio

Family:  TF

Novelty:  0.00687548

p_int:  0.999976692

p_ni:  0.000023308

Score:  0.188

Data Source:  BioPlex,STRINGDB

DEFA5

Tbio

Novelty:  0.00863727

p_int:  0.999974782

p_ni:  0.000025218

Data Source:  BioPlex

DEFA6

Tbio

Novelty:  0.0363171

p_int:  0.999922615

p_ni:  0.000077385

Score:  0.158

Data Source:  BioPlex,STRINGDB

CLMP

Tbio

Novelty:  0.01435374

p_int:  0.998257197

p_ni:  0.001742756

p_wrong:  4.7e-8

Score:  0.228

Data Source:  BioPlex,STRINGDB

GYPB

Tbio

Novelty:  0.00442195

p_int:  0.996789682

p_ni:  0.003196023

p_wrong:  0.000014296

Data Source:  BioPlex

EIF1AD

Tdark

Novelty:  0.23915521

p_int:  0.996761236

p_ni:  0.003236435

p_wrong:  0.000002329

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Downstream (3)

1 – 3 of 3

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  1

1: Phosphatidylinositol signaling system

IMPA1

Tclin

Family:  Enzyme

KEGG Distance:  5

Common Pathways:  1

1: Phosphatidylinositol signaling system

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  1

1: Phosphatidylinositol signaling system

Pathways (7)

Reactome (4)

KEGG (1)

PathwayCommons (2)

Inositol phosphate metabolism (R-HSA-1483249)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Inositol phosphate metabolism	48 targets	R-HSA-1483249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Synthesis of IPs in the nucleus	4 targets	R-HSA-1855191
Reactome	Synthesis of pyrophosphates in the cytosol	10 targets	R-HSA-1855167

Name	Explore in Pharos	Explore in Source
Inositol phosphate metabolism	48 targets	R-HSA-1483249
Metabolism	2112 targets	R-HSA-1430728
Synthesis of IPs in the nucleus	4 targets	R-HSA-1855191
Synthesis of pyrophosphates in the cytosol	10 targets	R-HSA-1855167

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (9)

Components (4)

Processes (4)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
inositol hexakisphosphate kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
inositol 5-diphosphate pentakisphosphate 5-kinase activity	Traceable Author Statement (TAS)	Reactome
inositol diphosphate tetrakisphosphate kinase activity	Traceable Author Statement (TAS)	Reactome
inositol heptakisphosphate kinase activity	Traceable Author Statement (TAS)	Reactome
inositol-1,3,4,5,6-pentakisphosphate kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
inositol hexakisphosphate 1-kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
inositol hexakisphosphate 3-kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
inositol hexakisphosphate 5-kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (50)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 50

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	8	9	8	4.6	99.2
intelligence	EFO_0004337	4	15	7	7.4	96.6
household income	EFO_0009695	2	7	8		95.8
reticulocyte count	EFO_0007986	1	2	2		93.4
mathematical ability	EFO_0004875	3	3	3		92.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 50

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	8	4.6	99.2
intelligence	EFO_0004337	7	7.4	96.6
household income	EFO_0009695	8		95.8
reticulocyte count	EFO_0007986	2		93.4
mathematical ability	EFO_0004875	3		92.6

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UniProt Keyword Find Similar Targets

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Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
apolipoprotein A 1 measurement
biological sex
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat percentage
body height
body mass index
C-reactive protein measurement
chronotype measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	inositol hexakisphosphate kinase 1	VGNC:1849	460379
Macaque	inositol hexakisphosphate kinase 1		705576
Mouse	inositol hexaphosphate kinase 1	MGI:1351633	27399
Rat	inositol hexakisphosphate kinase 1	RGD:71025	50560
Dog	inositol hexakisphosphate kinase 1	VGNC:42061	484765

Species	Name	OMA	EggNOG	Inparanoid
Chimp	inositol hexakisphosphate kinase 1
Macaque	inositol hexakisphosphate kinase 1
Mouse	inositol hexaphosphate kinase 1
Rat	inositol hexakisphosphate kinase 1
Dog	inositol hexakisphosphate kinase 1

Publication Statistics

PubMed Score 42.81

PubMed score by year

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PubTator Score 29.29

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (9)

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PMID	Year	Title