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Tbio
IP6K1
Inositol hexakisphosphate kinase 1

Protein Summary
Description
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321599
  • ENSP00000323780
  • ENSG00000176095
  • ENST00000395238
  • ENSP00000378659
  • ENST00000460540
  • ENSP00000420762
  • ENST00000613416
  • ENSP00000482032

Symbol
  • IHPK1
  • KIAA0263
  • PiUS
  • IHPK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
histone modification site profile
0.85
kinase perturbation
0.84
transcription factor perturbation
0.84
microRNA
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.81   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.81   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
TMEM134
Tdark
Novelty:  0.42629221
p_int:  0.99999999
p_ni:  9e-9
Data Source:  BioPlex
UBXN4
Tbio
Novelty:  0.16206743
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.679
Data Source:  BioPlex,STRINGDB
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.9999976
p_ni:  0.0000024
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999993228
p_ni:  0.000006772
Score:  0.23
Data Source:  BioPlex,STRINGDB
TFCP2
Tbio
Family:  TF
Novelty:  0.00687548
p_int:  0.999976692
p_ni:  0.000023308
Score:  0.188
Data Source:  BioPlex,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.999974782
p_ni:  0.000025218
Data Source:  BioPlex
DEFA6
Tbio
Novelty:  0.0363171
p_int:  0.999922615
p_ni:  0.000077385
Score:  0.158
Data Source:  BioPlex,STRINGDB
CLMP
Tbio
Novelty:  0.01435374
p_int:  0.998257197
p_ni:  0.001742756
p_wrong:  4.7e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
GYPB
Tbio
Novelty:  0.00442195
p_int:  0.996789682
p_ni:  0.003196023
p_wrong:  0.000014296
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.996761236
p_ni:  0.003236435
p_wrong:  0.000002329
Data Source:  BioPlex
Pathways (7)
Inositol phosphate metabolism (R-HSA-1483249)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IPs in the nucleus
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IPs in the nucleus
Synthesis of pyrophosphates in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
8
9
8
4.6
99.2
intelligence
4
15
7
7.4
96.6
household income
2
7
8
95.8
reticulocyte count
1
2
2
93.4
mathematical ability
3
3
3
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
8
4.6
99.2
intelligence
7
7.4
96.6
household income
8
95.8
reticulocyte count
2
93.4
mathematical ability
3
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol hexakisphosphate kinase 1
VGNC:1849
460379
Macaque
inositol hexakisphosphate kinase 1
705576
Mouse
MGI:1351633
27399
Rat
RGD:71025
50560
Dog
inositol hexakisphosphate kinase 1
VGNC:42061
484765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol hexakisphosphate kinase 1
Macaque
inositol hexakisphosphate kinase 1
Mouse
Rat
Dog
inositol hexakisphosphate kinase 1
Publication Statistics
PubMed Score 42.81
PubMed score by year
PubTator Score 29.29
PubTator score by year
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Related Publications
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PMID
Year
Title