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Tbio
INVS
Inversin

Protein Summary
Description
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262456
  • ENSP00000262456
  • ENSG00000119509
  • ENST00000262457
  • ENSP00000262457
  • ENST00000374921
  • ENSP00000364056

Symbol
  • INV
  • NPHP2
  • INV
  • NPH2
  • NPHP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.85
virus perturbation
0.79
cellular component
0.77
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.02   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.02   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
EXT2
Tbio
Family:  Enzyme
Novelty:  0.00480574
p_int:  0.999988048
p_ni:  3.18e-7
p_wrong:  0.000011635
Score:  0.359
Data Source:  BioPlex,STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.974
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.964
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.957
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.926
Data Source:  STRINGDB
NPHP3
Tbio
Novelty:  0.02857926
Score:  0.914
Data Source:  STRINGDB
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
Score:  0.877
Data Source:  STRINGDB
NEK8
Tchem
Family:  Kinase
Novelty:  0.00709572
Score:  0.873
Data Source:  STRINGDB
NPHP4
Tbio
Novelty:  0.02873746
Score:  0.853
Data Source:  STRINGDB
NEK9
Tchem
Family:  Kinase
Novelty:  0.02386353
Score:  0.83
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
64
body height
1
1
1
61
body weight
1
1
1
55.5
body mass index
1
1
1
45
body fat percentage
1
1
1
42.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
64
body height
1
61
body weight
1
55.5
body mass index
1
45
body fat percentage
1
42.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inversin
VGNC:4767
473146
Macaque
inversin
714490
Mouse
MGI:1335082
16348
Rat
RGD:1563359
313228
Dog
inversin
VGNC:42060
442950
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inversin
Macaque
inversin
Mouse
Rat
Dog
inversin
Publication Statistics
PubMed Score 118.02
PubMed score by year
PubTator Score 329.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title