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Tbio
INTU
Protein inturned

Protein Summary
Description
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335251
  • ENSP00000334003
  • ENSG00000164066
  • ENST00000503626
  • ENSP00000426287
  • ENST00000503952
  • ENSP00000421995

Symbol
  • KIAA1284
  • PDZD6
  • PDZK6
  • INT
  • OFD17
  • PDZD6
  • PDZK6
  • SRTD20
  • CPLANE4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
tissue
0.67
histone modification site profile
0.64
phenotype
0.58
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.35   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.35   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0