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Tdark
INTS8
Integrator complex subunit 8

Protein Summary
Description
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523731
  • ENSP00000430338
  • ENSG00000164941

Symbol
  • C8orf52
  • INT8
  • C8orf52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor perturbation
0.74
interacting protein
0.73
disease perturbation
0.68
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.9993821
p_ni:  0.000617899
p_wrong:  1e-9
Score:  0.9
Data Source:  BioPlex,STRINGDB
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.998829076
p_ni:  0.001170913
p_wrong:  1e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.986169662
p_ni:  0.010917886
p_wrong:  0.002912452
Score:  0.244
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.980382758
p_ni:  0.019258126
p_wrong:  0.000359116
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.980077409
p_ni:  0.019914609
p_wrong:  0.000007982
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.972836608
p_ni:  0.026681161
p_wrong:  0.000482231
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.942116465
p_ni:  0.052943677
p_wrong:  0.004939858
Score:  0.186
Data Source:  BioPlex,STRINGDB
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.883756824
p_ni:  0.110812
p_wrong:  0.005431176
Data Source:  BioPlex
VCAM1
Tchem
Novelty:  0.00022504
p_int:  0.868540903
p_ni:  0.101526826
p_wrong:  0.029932271
Score:  0.309
Data Source:  BioPlex,STRINGDB
INTS6
Tbio
Novelty:  0.02680242
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
6
5
3
1
97.3
central corneal thickness
3
2
0
2
94.7
urate measurement
2
2
2
91.6
hemoglobin measurement
4
4
4
87
hematocrit
2
2
2
82.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
1
97.3
central corneal thickness
0
2
94.7
urate measurement
2
91.6
hemoglobin measurement
4
87
hematocrit
2
82.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 8
VGNC:860
464291
Macaque
integrator complex subunit 8
700255
Mouse
MGI:1919906
72656
Rat
RGD:1310592
297823
Dog
integrator complex subunit 8
VGNC:42057
487056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 8
Macaque
integrator complex subunit 8
Mouse
Rat
Dog
integrator complex subunit 8
Publication Statistics
PubMed Score 67.56
PubMed score by year
PubTator Score 13.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title