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Tbio
INTS6
Integrator complex subunit 6

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311234
  • ENSP00000310260
  • ENSG00000102786
  • ENST00000398119
  • ENSP00000381187
  • ENST00000442263
  • ENSP00000411245

Symbol
  • DBI1
  • DDX26
  • DDX26A
  • HDB
  • INT6
  • DBI-1
  • DDX26
  • DICE1
  • DDX26A
  • Notchl2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
virus perturbation
0.98
microRNA
0.83
transcription factor binding site profile
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.88   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.88   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.999984491
p_ni:  0.000015509
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.999944971
p_ni:  0.000055029
Data Source:  BioPlex
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.999908377
p_ni:  0.000091623
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999651049
p_ni:  0.000348951
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.99962092
p_ni:  0.00037908
Score:  0.162
Data Source:  BioPlex,STRINGDB
TBL1Y
Tbio
p_int:  0.997989904
p_ni:  0.00201008
p_wrong:  1.6e-8
Data Source:  BioPlex
CTDSP2
Tbio
Family:  Enzyme
Novelty:  0.01033594
p_int:  0.997549703
p_ni:  0.002450295
p_wrong:  2e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
INTS3
Tbio
Novelty:  0.13398603
p_int:  0.994947942
p_ni:  0.005052058
Score:  0.999
Data Source:  BioPlex,STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
p_int:  0.987675226
p_ni:  0.012115964
p_wrong:  0.00020881
Score:  0.21
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.983324696
p_ni:  0.009510357
p_wrong:  0.007164948
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
81.1
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 6
VGNC:5068
452729
Macaque
integrator complex subunit 6
708618
Mouse
MGI:1202397
18130
Dog
integrator complex subunit 6
VGNC:42054
476905
Horse
integrator complex subunit 6
VGNC:19094
100053346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 6
Macaque
integrator complex subunit 6
Mouse
Dog
integrator complex subunit 6
Horse
integrator complex subunit 6
Publication Statistics
PubMed Score 41.88
PubMed score by year
PubTator Score 31.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title