Tbio INTS6 Integrator complex subunit 6

Protein Summary

Description

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth (PubMed:15254679, PubMed:16239144). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• Q9UL03
• Q0P664
• Q6PJP4
• Q9UFK0
• Q9Y5M9
• Int6

Gene Name

• INTS6

Ensembl ID

• ENST00000311234
• ENSP00000310260
• ENSG00000102786
• ENST00000398119
• ENSP00000381187
• ENST00000442263
• ENSP00000411245

Symbol

• DBI1
• DDX26
• DDX26A
• HDB
• INT6
• DBI-1
• DDX26
• DICE1
• DDX26A
• Notchl2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
virus perturbation	0.98
microRNA	0.83
transcription factor binding site profile	0.83
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Integrator Complex Subunit 6

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Integrator Complex Subunit 6

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Integrator Complex Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0