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Tbio
INTS5
Integrator complex subunit 5

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330574
  • ENSP00000327889
  • ENSG00000185085

Symbol
  • KIAA1698
  • INT5
  • KIAA1698
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
histone modification site profile
0.78
transcription factor binding site profile
0.7
cell line
0.67
cellular component
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.997713737
p_ni:  0.002286262
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.996146379
p_ni:  0.003853621
Score:  0.152
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.976422018
p_ni:  0.023577852
p_wrong:  1.3e-7
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.963289282
p_ni:  0.036687295
p_wrong:  0.000023422
Data Source:  BioPlex
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.949604319
p_ni:  0.050386921
p_wrong:  0.00000876
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.933927801
p_ni:  0.066072199
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.91612985
p_ni:  0.08387015
Data Source:  BioPlex
P01889
Tbio
Novelty:  0.00790207
p_int:  0.915940333
p_ni:  0.084059667
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
p_int:  0.90497788
p_ni:  0.09502212
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.900318063
p_ni:  0.099681937
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
8
9
90.5
waist-hip ratio
1
5
5
90.1
forced expiratory volume
1
1
1
78.3
waist circumference
1
3
3
75.9
vital capacity
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
90.5
waist-hip ratio
5
90.1
forced expiratory volume
1
78.3
waist circumference
3
75.9
vital capacity
1
73.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 5
VGNC:3114
740514
Mouse
MGI:1923578
109077
Rat
RGD:1309370
309200
Dog
integrator complex subunit 5
VGNC:42053
612216
Horse
integrator complex subunit 5
VGNC:19093
100063653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 5
Mouse
Rat
Dog
integrator complex subunit 5
Horse
integrator complex subunit 5
Publication Statistics
PubMed Score 45.14
PubMed score by year
PubTator Score 10.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title