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Tdark
INTS4
Integrator complex subunit 4

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000529807
  • ENSP00000433644
  • ENSG00000149262
  • ENST00000534064
  • ENSP00000434466
  • ENST00000535943
  • ENSP00000441084

Symbol
  • INT4
  • MST093
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.91
disease perturbation
0.87
kinase perturbation
0.84
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
SIGLECL1
Tdark
p_int:  0.999166464
p_ni:  0.000833536
Data Source:  BioPlex
BMP2K
Tchem
Family:  Kinase
Novelty:  0.10145601
p_int:  0.998542316
p_ni:  0.001457679
p_wrong:  6e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.992204058
p_ni:  0.007795942
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.992035721
p_ni:  0.007964279
Data Source:  BioPlex
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.991417692
p_ni:  0.008582308
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.990704784
p_ni:  0.009295216
Data Source:  BioPlex
TGOLN2
Tbio
Novelty:  0.005107
p_int:  0.988689216
p_ni:  0.011310784
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.987633996
p_ni:  0.012366004
Data Source:  BioPlex
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.97054988
p_ni:  0.02945012
Data Source:  BioPlex
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.969425301
p_ni:  0.030574699
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
62.1
platelet count
1
1
1
49.5
sex hormone-binding globulin measurement
2
1
2
40.7
mean reticulocyte volume
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
62.1
platelet count
1
49.5
sex hormone-binding globulin measurement
2
40.7
mean reticulocyte volume
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 4
VGNC:11842
451444
Macaque
integrator complex subunit 4
699466
Mouse
MGI:1917164
101861
Rat
RGD:1305036
308837
Dog
integrator complex subunit 4
476795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 4
Macaque
integrator complex subunit 4
Mouse
Rat
Dog
integrator complex subunit 4
Publication Statistics
PubMed Score 4.55
PubMed score by year
PubTator Score 2.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title