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Tbio
INTS3
Integrator complex subunit 3

Protein Summary
Description
Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318967
  • ENSP00000318641
  • ENSG00000143624
  • ENST00000435409
  • ENSP00000404290
  • ENST00000512605
  • ENSP00000425437
  • ENST00000571768
  • ENSP00000458631
  • ENSG00000262826
  • ENST00000576030
  • ENSP00000460221
  • ENST00000576422
  • ENSP00000459907

Symbol
  • C1orf193
  • C1orf60
  • INT3
  • SOSSA
  • SOSS-A
  • C1orf60
  • C1orf193
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor binding site profile
0.77
disease perturbation
0.74
histone modification site profile
0.73
transcription factor
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.999999848
p_ni:  1.52e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.996728167
p_ni:  0.003271833
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.995686871
p_ni:  0.004313129
Data Source:  BioPlex
INTS6
Tbio
Novelty:  0.02680242
p_int:  0.994947942
p_ni:  0.005052058
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.993202766
p_ni:  0.006797234
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.98315883
p_ni:  0.016841169
Data Source:  BioPlex
CPNE2
Tdark
Novelty:  0.24188419
p_int:  0.97830314
p_ni:  0.02169686
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.956078714
p_ni:  0.043921286
Data Source:  BioPlex
ST6GAL1
Tchem
Family:  Enzyme
Novelty:  0.00274127
p_int:  0.893958325
p_ni:  0.106041675
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZNF577
Tdark
Family:  TF
Novelty:  0.29636548
p_int:  0.766487492
p_ni:  0.233512508
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
3
3
86
mathematical ability
4
3
4
85.2
diet measurement
3
2
3
71.8
cognitive function measurement
3
1
3
65.9
body height
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
86
mathematical ability
4
85.2
diet measurement
3
71.8
cognitive function measurement
3
65.9
body height
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 3
VGNC:10668
457331
Mouse
MGI:2140050
229543
Rat
RGD:1304593
361988
Dog
integrator complex subunit 3
VGNC:42052
100855813
Horse
integrator complex subunit 3
VGNC:19092
100056524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 3
Mouse
Rat
Dog
integrator complex subunit 3
Horse
integrator complex subunit 3
Publication Statistics
PubMed Score 10.94
PubMed score by year
PubTator Score 5.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title