INTS2
Integrator complex subunit 2
Protein Summary
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
- ENST00000444766
- ENSP00000414237
- ENSG00000108506
- ENST00000617492
- ENSP00000482710
- KIAA1287
- INT2
- KIAA1287
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.65 | ||
microRNA | 0.63 | ||
tissue sample | 0.63 | ||
histone modification site profile | 0.62 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.74 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 60 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.74 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 60 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (146)
DPEP1
Family: Enzyme
Novelty: 0.00384946
p_int: 0.911274468
p_ni: 0.088725531
Data Source: BioPlex
CMKLR1
Family: GPCR
Novelty: 0.00893083
p_int: 0.895147367
p_ni: 0.104852633
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RNA polymerase II transcribes snRNA genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
RNA Polymerase II Transcription | ||||
RNA polymerase II transcribes snRNA genes | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (8)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | LIFEdb | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 61.4 | |||||
1 | 1 | 0 | 8 | 56.6 | |||||
self reported educational attainment | 1 | 1 | 1 | 53.7 | |||||
mean corpuscular volume | 1 | 1 | 1 | 53.3 | |||||
mathematical ability | 1 | 1 | 1 | 27.3 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 61.4 | |||||
0 | 8 | 56.6 | |||||
self reported educational attainment | 1 | 53.7 | |||||
mean corpuscular volume | 1 | 53.3 | |||||
mathematical ability | 1 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrator complex subunit 2 | VGNC:9335 | 454794 | |||||
Macaque | integrator complex subunit 2 | 712351 | ||||||
Mouse | MGI:1917672 | 70422 | ||||||
Dog | integrator complex subunit 2 | VGNC:42051 | 610121 | |||||
Horse | integrator complex subunit 2 | VGNC:19091 | 100071151 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrator complex subunit 2 | |||||
Macaque | integrator complex subunit 2 | |||||
Mouse | ||||||
Dog | integrator complex subunit 2 | |||||
Horse | integrator complex subunit 2 | |||||
Publication Statistics
PubMed Score 3.74
PubMed score by year
PubTator Score 0.67
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (2)
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0 of 0
PMID | Year | Title |
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