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Tdark
INTS2
Integrator complex subunit 2

Protein Summary
Description
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000444766
  • ENSP00000414237
  • ENSG00000108506
  • ENST00000617492
  • ENSP00000482710

Symbol
  • KIAA1287
  • INT2
  • KIAA1287
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.65
microRNA
0.63
tissue sample
0.63
histone modification site profile
0.62
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
CD70
Tbio
Novelty:  0.00420393
p_int:  0.997682287
p_ni:  0.002317713
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.995639295
p_ni:  0.004360705
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.985513369
p_ni:  0.014486631
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.974223379
p_ni:  0.025776621
Data Source:  BioPlex
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.961148981
p_ni:  0.038851019
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.957329968
p_ni:  0.042670032
Data Source:  BioPlex
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.911274468
p_ni:  0.088725531
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.895147367
p_ni:  0.104852633
Data Source:  BioPlex
FAS
Tbio
Novelty:  0.00043286
p_int:  0.881516778
p_ni:  0.118483222
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.865655897
p_ni:  0.134344103
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
61.4
1
1
0
8
56.6
self reported educational attainment
1
1
1
53.7
mean corpuscular volume
1
1
1
53.3
mathematical ability
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
61.4
0
8
56.6
self reported educational attainment
1
53.7
mean corpuscular volume
1
53.3
mathematical ability
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 2
VGNC:9335
454794
Macaque
integrator complex subunit 2
712351
Mouse
MGI:1917672
70422
Dog
integrator complex subunit 2
VGNC:42051
610121
Horse
integrator complex subunit 2
VGNC:19091
100071151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrator complex subunit 2
Macaque
integrator complex subunit 2
Mouse
Dog
integrator complex subunit 2
Horse
integrator complex subunit 2
Publication Statistics
PubMed Score 3.74
PubMed score by year
PubTator Score 0.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title